Nanomedicine for improvement of dendritic cell-based cancer immunotherapy

Background: Dendritic cell (DC)-based cancer immunotherapy has shown impressive outcomes, including the development of the first FDA-approved anti-cancer vaccine. However, the clinical application of DC-based cancer immunotherapy is associated with various challenges. Promising novel tools for the administration of cancer vaccines has emerged from recent developments in nanoscale biomaterials. One current strategy to enhance targeted drug delivery, while minimizing drug-related toxicities, is the use of nanoparticles (NPs).Method: In this study, PubMed-Medline and Embase databases were searched for publications related to Nanoparticle for cancer immunotherapy. The data was extracted from the existing publications and used. Also, most of the data were for tests of foreign studies.Results: These can be utilized for antigen delivery into DCs, which have been shown to provide potent T cell-stimulating effects. Therefore, NP delivery represents one promising approach for creating an effective and stable immune response without toxic side effects.Conclusion: The current review surveys cancer immunotherapy with particular attention toward NP-based delivery methods that target DCs