UBE2E1

UBE2E1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XR9, 3BZH, 4JJQ
Identifiers
Aliases	UBE2E1, UBCH6, ubiquitin conjugating enzyme E2 E1
External IDs	OMIM: 602916; MGI: 107411; HomoloGene: 84372; GeneCards: UBE2E1; OMA:UBE2E1 - orthologs
EC number	2.3.2.24
Gene location (Human)
Chr.	Chromosome 3 (human)
End	23,891,640 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	4,186,974 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; oral cavity; ; ventricular zone; ; embryo; ; skin of arm; ; superficial temporal artery; ; bronchial epithelial cell; ; mucosa of paranasal sinus; ; Pons; ; lower lobe of lung;
	Top expressed in
	otic placode; ; otic vesicle; ; saccule; ; mammillary body; ; ventral tegmental area; ; dorsomedial hypothalamic nucleus; ; arcuate nucleus; ; paraventricular nucleus of hypothalamus; ; nasal epithelium; ; olfactory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; ISG15 transferase activity; ubiquitin-protein transferase activity; protein binding; ATP binding; ubiquitin conjugating enzyme activity;
Cellular component	cytosol; ubiquitin ligase complex; nucleoplasm; nucleus;
Biological process	histone monoubiquitination; ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein K48-linked ubiquitination; ISG15-protein conjugation; anaphase-promoting complex-dependent catabolic process; histone H2B ubiquitination; protein ubiquitination; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	7324
	22194
	ENSG00000170142
	ENSMUSG00000021774
	P51965
	P52482
	NM_001202476; NM_003341; NM_182666
	NM_009455
	NP_001189405; NP_003332; NP_872607; NP_003332.1
	NP_033481
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene.^[5]^[6]

Function

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[6]

Interactions

UBE2E1 has been shown to interact with Ataxin 1^[7] and NEDD4.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170142 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021774 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M (Mar 1996). "Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5". J. Biol. Chem. 271 (5): 2795–800. doi:10.1074/jbc.271.5.2795. PMID 8576257.
^ ^a ^b "Entrez Gene: UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)".
^ Hong S, Lee S, Cho SG, Kang S (Jun 2008). "UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1". Biochem. Biophys. Res. Commun. 371 (2): 256–60. doi:10.1016/j.bbrc.2008.04.066. PMID 18439907.
^ Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (Nov 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells. 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. PMID 9990509. S2CID 1653536.
^ Malakhova OA, Zhang DE (Apr 2008). "ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response". J. Biol. Chem. 283 (14): 8783–7. doi:10.1074/jbc.C800030200. PMC 2276364. PMID 18287095.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Ubiquitin-conjugating enzyme E2 E1 (UBE2E1)

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170142 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021774 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8576257-5] Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M (Mar 1996). "Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5". J. Biol. Chem. 271 (5): 2795–800. doi:10.1074/jbc.271.5.2795. PMID 8576257.

[entrez-6] "Entrez Gene: UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)".

[pmid18439907-7] Hong S, Lee S, Cho SG, Kang S (Jun 2008). "UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1". Biochem. Biophys. Res. Commun. 371 (2): 256–60. doi:10.1016/j.bbrc.2008.04.066. PMID 18439907.

[pmid9990509-8] Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (Nov 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells. 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. PMID 9990509. S2CID 1653536.

[pmid18287095-9] Malakhova OA, Zhang DE (Apr 2008). "ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response". J. Biol. Chem. 283 (14): 8783–7. doi:10.1074/jbc.C800030200. PMC 2276364. PMID 18287095.

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Function

Interactions

References

Further reading

External links