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Protein-coding gene in the species Homo sapiens
Tuftelin is an acidic phosphorylated glycoprotein found in tooth enamel . In humans, the tuftelin protein is encoded by the TUFT1 gene.[ 5] [ 6] [ 7]
There are two kinds of enamel proteins: amelogenins and nonamelogenins. Tuftelin falls under nonamelogenins.[ 8]
This protein is formed for a short time during amelogenesis . The function of tuftelins is under contention, but it is proposed that it acts to start the mineralization process of enamel during tooth development .[ 9] [ 10]
Other significant proteins in enamel are amelogenins , enamelins , and ameloblastins .
The human encoding gene for tuftelin (TUFT1) was cloned by Profs. Danny Deutsch and Aharon Palmon from the Hebrew University -Hadassah School of Dental Medicine in Jerusalem .[ 6]
Tuftelin has been shown to interact with TFIP11 .[ 11]
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