RTI-352
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| Names | |
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| IUPAC name
Methyl 3α-(4-iodophenyl)tropane-2β-carboxylate
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| Systematic IUPAC name
Methyl (1R,2S,3R,5S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate | |
| Other names
RTI-4229-352
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
PubChem CID
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| C16H20INO2 | |
| Molar mass | 385.245 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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RTI-352 is a phenyltropane that is used as a radiolabeling ligand for the DAT.[1]
RTI-352 is a geometric isomer of RTI-55 (β-CIT).[2]
Based on X-ray crystallography, this compound is in a tautomeric equilibrium residing mostly on the side of the boat-shaped conformer.
References
[edit]- ^ U.S. patent 6,358,492
- ^ Zhan, Yougen; Saindane, Amit M.; Scheffel, Ursula; Carroll, F. Ivy; Holmquist, Christopher R.; Kepler, John A.; Taylor, George F.; Kuhar, Michael J. (1997). "RTI-352: A 3α Analogue of RTI-55 as an in vivo dopamine transporter binding ligand". Synapse. 25 (4): 389–392. doi:10.1002/(SICI)1098-2396(199704)25:4<389::AID-SYN10>3.0.CO;2-Q. PMID 9097398.
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