NOXO1

NOXO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L73
Identifiers
Aliases	NOXO1, P41NOX, P41NOXA, P41NOXB, P41NOXC, SH3PXD5, SNX28, NADPH oxidase organizer 1
External IDs	OMIM: 611256; MGI: 1919143; HomoloGene: 12418; GeneCards: NOXO1; OMA:NOXO1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	1,984,192 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	24,919,503 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; gonad; ; testicle; ; rectum; ; appendix; ; olfactory zone of nasal mucosa; ; right hemisphere of cerebellum; ; mucosa of sigmoid colon; ; right lobe of liver; ; left testis;
	Top expressed in
	Paneth cell; ; crypt of lieberkuhn of small intestine; ; spermatocyte; ; large intestine; ; colon; ; left colon; ; ileum; ; spermatid; ; jejunum; ; intestinal villus;
	More reference expression data
	n/a
Gene ontology
Molecular function	enzyme binding; superoxide-generating NADPH oxidase activator activity; protein binding; phospholipid binding; identical protein binding; lipid binding; phosphatidylinositol binding;
Cellular component	plasma membrane; NADPH oxidase complex; membrane; intracellular anatomical structure;
Biological process	regulation of respiratory burst; extracellular matrix disassembly; positive regulation of catalytic activity; regulation of hydrogen peroxide metabolic process; superoxide metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	124056
	71893
	ENSG00000196408
	ENSMUSG00000019320
	Q8NFA2
	Q8VCM2
	NM_001267721; NM_144603; NM_172167; NM_172168
	NM_027988; NM_001357836
	NP_001254650; NP_653204; NP_751907; NP_751908
	NP_082264; NP_001344765
	Wikidata
View/Edit Human	View/Edit Mouse

NADPH oxidase organizer 1 is an enzyme that in humans is encoded by the NOXO1 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196408 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019320 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: NOXO1 NADPH oxidase organizer 1".

Bánfi B, Clark RA, Steger K, Krause KH (2003). "Two novel proteins activate superoxide generation by the NADPH oxidase NOX1". J. Biol. Chem. 278 (6): 3510–3. doi:10.1074/jbc.C200613200. PMID 12473664.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Geiszt M, Lekstrom K, Witta J, Leto TL (2003). "Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells". J. Biol. Chem. 278 (22): 20006–12. doi:10.1074/jbc.M301289200. PMID 12657628.
Takeya R, Ueno N, Kami K, et al. (2003). "Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases". J. Biol. Chem. 278 (27): 25234–46. doi:10.1074/jbc.M212856200. PMID 12716910.
Cheng G, Lambeth JD (2004). "NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain". J. Biol. Chem. 279 (6): 4737–42. doi:10.1074/jbc.M305968200. PMID 14617635.
Cheng G, Ritsick D, Lambeth JD (2004). "Nox3 regulation by NOXO1, p47phox, and p67phox". J. Biol. Chem. 279 (33): 34250–5. doi:10.1074/jbc.M400660200. PMID 15181005.
Bánfi B, Malgrange B, Knisz J, et al. (2004). "NOX3, a superoxide-generating NADPH oxidase of the inner ear". J. Biol. Chem. 279 (44): 46065–72. doi:10.1074/jbc.M403046200. PMID 15326186.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ueno N, Takeya R, Miyano K, et al. (2005). "The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators". J. Biol. Chem. 280 (24): 23328–39. doi:10.1074/jbc.M414548200. PMID 15824103.
Cheng G, Lambeth JD (2005). "Alternative mRNA splice forms of NOXO1: differential tissue expression and regulation of Nox1 and Nox3". Gene. 356: 118–26. doi:10.1016/j.gene.2005.03.008. PMID 15949904.
Park HS, Park D, Bae YS (2006). "Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1". Biochem. Biophys. Res. Commun. 339 (3): 985–90. doi:10.1016/j.bbrc.2005.11.108. PMID 16329988.
Takeya R, Taura M, Yamasaki T, et al. (2006). "Expression and function of Noxo1gamma, an alternative splicing form of the NADPH oxidase organizer 1". FEBS J. 273 (16): 3663–77. doi:10.1111/j.1742-4658.2006.05371.x. PMID 16911517. S2CID 701568.
Yamamoto A, Kami K, Takeya R, Sumimoto H (2007). "Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1)". Biochem. Biophys. Res. Commun. 352 (2): 560–5. doi:10.1016/j.bbrc.2006.11.060. PMID 17126813.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human NADPH oxidase organizer 1

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196408 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019320 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: NOXO1 NADPH oxidase organizer 1".

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[5]

v t e Sorting nexins
SNX-BAR	SNX1 SNX2 SNX4 SNX5 SNX6 SNX7 SNX8 SNX9 SNX18 SNX30 SNX32 SNX33
SNX-PX	SNX3 SNX10 SNX11 SNX12 SNX16 SNX20 SNX21 SNX22 SNX24 SNX29
SNX-Other	SNX13 SNX14 SNX15 SNX17 SNX19 SNX23 SNX25 SNX26 SNX27 SNX28 SNX31
Related articles	PX domain BAR domain Retromer

References

Further reading

External links