File:Steroidogenesis.png

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Summary

DescriptionSteroidogenesis.png	English: Enzymes, their cellular location, substrates and products in human steroidogenesis. Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens. However, they partly overlap, e.g. mineralocorticoids and glucocorticoids. White circles indicate changes in molecular structure compared with precursors. For more information on interpretation of molecular structures, see structural formula. Arrows are shown as unidirectional to indicate the usual net directions, but technically all biochemical reactions are considered bidirectional. HSD: Hydroxysteroid dehydrogenase References:* Boron WF, Boulpaep EL (2003) Medical Physiology: A Cellular And Molecular Approach, Elsevier/Saunders, pp. page 1,300 ISBN: 1-4160-2328-3. For the absence of conversion of corticosterone to cortisol: Steroid hormone biosynthesis Reference pathway (KO). KEGG: Kyoto Encyclopedia of Genes and Genomes. Kyoto University Bioinformatics Center. (1 November 2013). There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21-OH steroids are poor substrates for 17-alpha hydroxylase. Further reading: Hanukoglu I (1992). "Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis". The Journal of Steroid Biochemistry and Molecular Biology 43 (8): 779–804. DOI:10.1016/0960-0760(92)90307-5. PMID 22217824. Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". Endocrine Reviews 25 (6): 947–70. DOI:10.1210/er.2003-0030. PMID 15583024. See also: Wikipedia:Steroidogenesis Wikiversity:Diagram of the pathways of human steroidogenesis Polski: Enzymy biorące udział w steroidogenezie. Uwagi: W miejscu gdzie stereochemia nie jest wyświetlana, jest taka sama jak dla Cholesterol lub w pokazanej powyżej grupie. HSD: Dehydrogenaza hydroksysteroidu Русский: Ферменты, участвующие в стероидогенезе человека, с указанием субстратов и продуктов, а также локализации их активности. Происходящие изменения в структуре молекул отмечены белыми кружочками. По сборнику "Медицинская физиология" (Walter F. Boron, Emile L. Boulpaep, 2003 год). 日本語: この図はヒトのステロイドホルモン生成における酵素と酵素が存在する細胞器官、基質ならびに生成物の全体図である。またこの図は（コレステロールから）プロゲステロン、鉱質コルチコイド、糖質コルチコイド、そしてアンドロゲンおよびエストロゲンに至る主要なステロイドを記述している。図に示すとおりそれぞれ（生合成の過程で）オーバーラップするものである。図中、白い円で囲んだところは基質と比較した分子構造の変化した箇所を示す。なお、HSD は、ヒドロキシステロイドデヒドロゲナーゼを表す。
Date	28 March 2009
Source	Häggström M, Richfield D (2014). "Diagram of the pathways of human steroidogenesis". WikiJournal of Medicine 1 (1). DOI:10.15347/wjm/2014.005. ISSN 20024436.
Author	David Richfield (Slashme) and Mikael Häggström. Derived from previous version by Hoffmeier and Settersr. In external use, this diagram may be cited as: (2014). "Diagram of the pathways of human steroidogenesis". WikiJournal of Medicine 1 (1). DOI:10.15347/wjm/2014.005. ISSN 20018762.
Other versions	edit Original. See also Evolution. Raster (.png) version is available Translations 中文國語 Русский Galego العربية polski German 日本語
PNG development InfoField	This structural formula was created with Inkscape. The chemistry symbols of this structural formula are drawn using the path text method.

Evolution

A short flashback of some milestones the evolution of the picture, demonstrating the power of free licensing where anybody can contribute to making things better.

1. (March 2007) Previous image by Stannered.

4. (August 2008) Vector (.svg) version by Slashme.

2. (July 2007) Molecular structures added by Hoffmeier and Settersr.

5. (March 2009) Expansion, grouping, addition of enzyme localization, numbering of cholesterol and coloring by Mikael Häggström.

3. (November 2007) Organization and addition of enzymes by Mikael Häggström.

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File history

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	Date/Time	Dimensions	User	Comment
current	15:22, 13 March 2013	2,075 × 1,842 (940 KB)	Slashme	Removed link from corticosterone to cortisol via CYP17A1, which is incorrect (according to http://www.genome.jp/kegg-bin/show_pathway?ko00140+C02140 )
	16:15, 9 July 2012	2,075 × 1,842 (932 KB)	Mikael Häggström	Addition and correction of stereochemistries at positions 11 and 17.
	04:24, 9 July 2012	2,075 × 1,842 (928 KB)	Mikael Häggström	Added stereochemistries, removed redundant white circle at cortisol, renamed 21-alpha hydroxylase to simply 21-hydroxylase.
	05:17, 13 December 2011	1,314 × 1,166 (530 KB)	Slashme	Align some text and arrows for neatness' sake.
	05:03, 13 December 2011	1,314 × 1,166 (530 KB)	Slashme	Fixed reaction scheme: corticosterone doesn't go to cortisol! Karl and Lindie, why didn't you fix it when you first found out? Tsk tsk.
	12:56, 8 May 2010	1,314 × 1,162 (510 KB)	Mikael Häggström	minor renaming of 3-beta-HSD
	09:28, 18 April 2010	1,314 × 1,162 (510 KB)	Mikael Häggström	Moved pregnenolone out of molecular structure
	08:54, 1 November 2009	1,003 × 883 (253 KB)	Mikael Häggström	"Bunny-jumped", since the change earlier probably was too small to make it want to really update, but that misplaced 6 was important.
	08:53, 1 November 2009	621 × 767 (428 KB)	Mikael Häggström	see above
	08:49, 1 November 2009	1,003 × 883 (253 KB)	Mikael Häggström	moved misplaced nr 6