ADAM2

ADAM2
Identifiers
Aliases	ADAM2, CRYN1, CRYN2, CT15, FTNB, PH-30b, PH30, PH30-beta, ADAM metallopeptidase domain 2
External IDs	OMIM: 601533; MGI: 1340894; HomoloGene: 1127; GeneCards: ADAM2; OMA:ADAM2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	39,838,227 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	66,315,182 bp
RNA expression pattern
	Top expressed in
	testicle; ; left testis; ; right testis; ; testicle; ; gonad; ; placenta; ; myeloid leukocyte; ; monocyte; ; prostate; ; appendix;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; morula; ; blastocyst; ; duodenum; ; neural tube; ; endocrine system; ; islet of Langerhans; ; digastric muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	integrin binding; metalloendopeptidase activity; metallopeptidase activity;
Cellular component	integral component of membrane; cell surface; plasma membrane; integral component of plasma membrane; membrane; protein-containing complex;
Biological process	visual learning; fusion of sperm to egg plasma membrane involved in single fertilization; cell adhesion; adult behavior; proteolysis; binding of sperm to zona pellucida; single fertilization; positive regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologs
	2515
	11495
	ENSG00000104755; ENSG00000276286
	ENSMUSG00000022039
	Q99965
	Q60718
	NM_001278113; NM_001278114; NM_001464
	NM_009618
	NP_001265042; NP_001265043; NP_001455
	NP_033748
	Wikidata
View/Edit Human	View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 2 or Beta-fertilin^[5] is an enzyme that in humans is encoded by the ADAM2 gene.^[6]^[7]^[8]

Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane heterodimer glycoprotein called fertilin, which plays an important role in sperm-egg interactions.^[8] The other subunit is ADAM1 or alpha-fertilin.^[5]

References

^ ^a ^b ^c ENSG00000276286 GRCh38: Ensembl release 89: ENSG00000104755, ENSG00000276286 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022039 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Fàbrega A, Guyonnet B, Dacheux JL, Gatti JL, Puigmulé M, Bonet S, Pinart E (June 2011). "Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (Sus domesticus) spermatozoa during epididymal maturation". Reproductive Biology and Endocrinology. 9: 96. doi:10.1186/1477-7827-9-96. PMC 3141649. PMID 21718510.
^ Gupta SK, Alves K, Palladino LO, Mark GE, Hollis GF (July 1996). "Molecular cloning of the human fertilin beta subunit". Biochemical and Biophysical Research Communications. 224 (2): 318–26. doi:10.1006/bbrc.1996.1027. PMID 8702389.
^ Burkin HR, Burkin DJ, Davey PM, Griffin DK, Affara NA (February 1997). "Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB)". Genomics. 40 (1): 190–2. doi:10.1006/geno.1996.4531. PMID 9070941.
^ ^a ^b "Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)".

External links

The MEROPS online database for peptidases and their inhibitors: M12.950
Human ADAM2 genome location and ADAM2 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000276286 GRCh38: Ensembl release 89: ENSG00000104755, ENSG00000276286 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022039 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[fertilin-5] Fàbrega A, Guyonnet B, Dacheux JL, Gatti JL, Puigmulé M, Bonet S, Pinart E (June 2011). "Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (Sus domesticus) spermatozoa during epididymal maturation". Reproductive Biology and Endocrinology. 9: 96. doi:10.1186/1477-7827-9-96. PMC 3141649. PMID 21718510.

[pmid8702389-6] Gupta SK, Alves K, Palladino LO, Mark GE, Hollis GF (July 1996). "Molecular cloning of the human fertilin beta subunit". Biochemical and Biophysical Research Communications. 224 (2): 318–26. doi:10.1006/bbrc.1996.1027. PMID 8702389.

[pmid9070941-7] Burkin HR, Burkin DJ, Davey PM, Griffin DK, Affara NA (February 1997). "Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB)". Genomics. 40 (1): 190–2. doi:10.1006/geno.1996.4531. PMID 9070941.

[entrez-8] "Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)".

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v t e Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Function

References

Further reading

External links