ANGPT2

ANGPT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z3S, 1Z3U, 2GY7, 4JZC, 4ZFG
Identifiers
Aliases	ANGPT2, AGPT2, ANG2, angiopoietin 2, LMPHM10
External IDs	OMIM: 601922; MGI: 1202890; HomoloGene: 22401; GeneCards: ANGPT2; OMA:ANGPT2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	6,563,409 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	18,791,578 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; popliteal artery; ; tibial arteries; ; placenta; ; islet of Langerhans; ; visceral pleura; ; subcutaneous adipose tissue; ; pericardium; ; internal globus pallidus; ; buccal mucosa cell;
	Top expressed in
	gastrula; ; endothelial cell of lymphatic vessel; ; decidua; ; lumbar spinal ganglion; ; external carotid artery; ; internal carotid artery; ; ascending aorta; ; umbilical cord; ; stroma of kidney; ; stroma of bone marrow;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; signaling receptor binding; protein binding; receptor tyrosine kinase binding;
Cellular component	cell projection; nucleus; plasma membrane; extracellular region; extracellular space;
Biological process	angiogenesis; response to hypoxia; response to mechanical stimulus; negative regulation of positive chemotaxis; response to radiation; negative regulation of cell-substrate adhesion; signal transduction; animal organ regeneration; response to activity; Tie signaling pathway; cellular response to growth factor stimulus; multicellular organism development; maternal process involved in female pregnancy; negative regulation of angiogenesis; response to organic cyclic compound; leukocyte migration; negative regulation of blood vessel endothelial cell migration; blood vessel morphogenesis; germ cell development; positive regulation of angiogenesis; response to glucose; cell differentiation; glomerulus vasculature development;
	Sources:Amigo / QuickGO
Orthologs
	285
	11601
	ENSG00000091879
	ENSMUSG00000031465
	O15123
	O35608
NM_001147; NM_001118887; NM_001118888; NM_001386335; NM_001386336;
	NM_001386337
	NM_007426
	NP_001112359; NP_001112360; NP_001138
	NP_031452
	Wikidata
View/Edit Human	View/Edit Mouse

Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene.^[5]

Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1^[6]

Function

See Angiopoietin#Clinical relevance

Interactions

ANGPT2 has been shown to interact with TEK tyrosine kinase.^[7]^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000091879 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031465 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cheung AH, Stewart RJ, Marsden PA (March 1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23". Genomics. 48 (3): 389–91. doi:10.1006/geno.1997.5207. PMID 9545648.
^ "Entrez Gene: ANGPT2 angiopoietin 2".
^ Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, Martiny-Baron G, Marmé D, Augustin HG (January 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". The Journal of Biological Chemistry. 278 (3): 1721–7. doi:10.1074/jbc.M208550200. PMID 12427764.
^ Sato A, Iwama A, Takakura N, Nishio H, Yancopoulos GD, Suda T (August 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". International Immunology. 10 (8): 1217–27. doi:10.1093/intimm/10.8.1217. PMID 9723709.
^ Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD (July 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55–60. doi:10.1126/science.277.5322.55. PMID 9204896.

External links

Human ANGPT2 genome location and ANGPT2 gene details page in the UCSC Genome Browser.

Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD (July 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55–60. doi:10.1126/science.277.5322.55. PMID 9204896.
Sato A, Iwama A, Takakura N, Nishio H, Yancopoulos GD, Suda T (August 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". International Immunology. 10 (8): 1217–27. doi:10.1093/intimm/10.8.1217. PMID 9723709.
Tanaka S, Mori M, Sakamoto Y, Makuuchi M, Sugimachi K, Wands JR (February 1999). "Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma". The Journal of Clinical Investigation. 103 (3): 341–5. doi:10.1172/JCI4891. PMC 407900. PMID 9927494.
Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, Yancopoulos GD (March 1999). "Angiopoietins 3 and 4: diverging gene counterparts in mice and humans". Proceedings of the National Academy of Sciences of the United States of America. 96 (5): 1904–9. Bibcode:1999PNAS...96.1904V. doi:10.1073/pnas.96.5.1904. PMC 26709. PMID 10051567.
Grosios K, Leek JP, Markham AF, Yancopoulos GD, Jones PF (1999). "Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping". Cytogenetics and Cell Genetics. 84 (1–2): 118–20. doi:10.1159/000015235. PMID 10343124. S2CID 40232421.
Procopio WN, Pelavin PI, Lee WM, Yeilding NM (October 1999). "Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity". The Journal of Biological Chemistry. 274 (42): 30196–201. doi:10.1074/jbc.274.42.30196. PMID 10514510.
Kim I, Kim JH, Ryu YS, Jung SH, Nah JJ, Koh GY (June 2000). "Characterization and expression of a novel alternatively spliced human angiopoietin-2". The Journal of Biological Chemistry. 275 (24): 18550–6. doi:10.1074/jbc.M910084199. PMID 10766762.
Mezquita J, Mezquita P, Montserrat P, Mezquita B, Francone V, Vilagrasa X, Mezquita C (August 2000). "Genomic structure and alternative splicing of chicken angiopoietin-2". Biochemical and Biophysical Research Communications. 275 (2): 643–51. doi:10.1006/bbrc.2000.3345. PMID 10964717.
Xu Y, Yu Q (September 2001). "Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region". The Journal of Biological Chemistry. 276 (37): 34990–8. doi:10.1074/jbc.M103661200. PMID 11447223.
Acker T, Beck H, Plate KH (October 2001). "Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and -2 suggests an important role of astrocytes in cerebellar vascularization". Mechanisms of Development. 108 (1–2): 45–57. doi:10.1016/S0925-4773(01)00471-3. PMID 11578860. S2CID 18841951.
Ward EG, Grosios K, Markham AF, Jones PF (2002). "Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2". Cytogenetics and Cell Genetics. 94 (3–4): 147–54. doi:10.1159/000048807. PMID 11856872. S2CID 22445942.
Huang YQ, Li JJ, Hu L, Lee M, Karpatkin S (March 2002). "Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells". Blood. 99 (5): 1646–50. doi:10.1182/blood.V99.5.1646. PMID 11861279.
Hata K, Udagawa J, Fujiwaki R, Nakayama K, Otani H, Miyazaki K (2002). "Expression of angiopoietin-1, angiopoietin-2, and Tie2 genes in normal ovary with corpus luteum and in ovarian cancer". Oncology. 62 (4): 340–8. doi:10.1159/000065066. PMID 12138242. S2CID 40689314.
Lin S, Shyu KG, Lee CC, Wang BW, Chang CC, Liu YC, Huang FY, Chang H (August 2002). "Hyperbaric oxygen selectively induces angiopoietin-2 in human umbilical vein endothelial cells". Biochemical and Biophysical Research Communications. 296 (3): 710–5. doi:10.1016/S0006-291X(02)00924-5. PMID 12176040.
Geva E, Ginzinger DG, Zaloudek CJ, Moore DH, Byrne A, Jaffe RB (September 2002). "Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2". The Journal of Clinical Endocrinology and Metabolism. 87 (9): 4213–24. doi:10.1210/jc.2002-020195. PMID 12213874.
Paradis V, Bièche I, Dargère D, Laurendeau I, Nectoux J, Degott C, Belghiti J, Vidaud M, Bedossa P (March 2003). "A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia". Gastroenterology. 124 (3): 651–9. doi:10.1053/gast.2003.50104. PMID 12612904.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000091879 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031465 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9545648-5] Cheung AH, Stewart RJ, Marsden PA (March 1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23". Genomics. 48 (3): 389–91. doi:10.1006/geno.1997.5207. PMID 9545648.

[6] "Entrez Gene: ANGPT2 angiopoietin 2".

[pmid12427764-7] Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, Martiny-Baron G, Marmé D, Augustin HG (January 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". The Journal of Biological Chemistry. 278 (3): 1721–7. doi:10.1074/jbc.M208550200. PMID 12427764.

[pmid9723709-8] Sato A, Iwama A, Takakura N, Nishio H, Yancopoulos GD, Suda T (August 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". International Immunology. 10 (8): 1217–27. doi:10.1093/intimm/10.8.1217. PMID 9723709.

[pmid9204896-9] Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD (July 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55–60. doi:10.1126/science.277.5322.55. PMID 9204896.

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v t e Antiangiogenics
Endogenous	Angiopoietin 2 angiostatin canstatin calreticulin endostatin IFN-α IFN-β IFN-γ CXCL10 IL-4 IL-12 IL-18 maspin Meth-1 Meth-2 osteopontin platelet factor-4 prolactin proliferin-related protein prothrombin (kringle domain-2) antithrombin III fragment SPARC Thrombospondin 1 TIMP vasostatin VEGI soluble VEGFR-1 NRP-1 CDAI
Exogenous	2-Methoxyestradiol α_Vβ₃ inhibitors angiostatic steroids heparin angiostatin bevacizumab carboxyamidotriazole Cartilage-Derived Angiogenesis Inhibitory Factor CM101 endostatin IFN-α IL-12 itraconazole linomide matrix metalloproteinase inhibitors platelet factor-4 prolactin SU5416 suramin tasquinimod tecogalan tetrathiomolybdate thalidomide thrombospondin thrombospondin TNP-470 VEGFR antagonists
See also	Angiogenesis Angiogenesis inhibitors

v t e Proteins involved in angiogenesis
angiogenic	Angiogenin Angiopoietin (ANGPT1, ANGPT2) Perlecan Vascular endothelial growth factor (A, B, C, D, PGF)
anti-angiogenic	Angiostatin Endostatin
See also Proteases in angiogenesis

Function

Interactions

See also

References

External links

Further reading