Senescence, a cell-autonomous tumour suppressor mechanism, also has pro-tumorigenic effects on neighbouring pre-malignant cells through the senescence-associated secretory phenotype (SASP). The SASP is now shown to be regulated by inflammasomes and to induce paracrine senescence in healthy cells, indicating that senescence may also represent a non-cell-autonomous tumour suppressor mechanism linked to innate immunity.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
£139.00 per year
only £11.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kuilman, T. & Peeper, D. S. Nat. Rev. Cancer 9, 81–94 (2009).
Krtolica, A. et al. Proc. Natl Acad. Sci. USA 98, 12072–12077 (2001).
Acosta, J. C. et al. Cell 133, 1006–1018 (2008).
Kuilman, T. et al. Cell 133, 1019–1031 (2008).
Wajapeyee, N. et al. Cell 132, 363–374 (2008).
Coppé, J. et al. PLoS Biol. 6, 2853–2868 (2008).
Kang, T-W. et al. Nature 479, 547–551 (2011).
Hubackova, S., Krejcikova, K., Bartek, J. & Hodny, Z. Aging 4, 932–951 (2012).
Acosta, J. C. et al. Nat. Cell Biol. 15, 978–990 (2013).
Kortlever, R. M., Higgins, P. J. & Bernards, R. Nat. Cell Biol. 8, 877–884 (2006).
Orjalo, A. V. et al. Proc. Natl Acad. Sci. USA 106, 17031–17036 (2009).
Strowig, T., Henao-Mejia, J., Elinav, E. & Flavell, R. Nature 481, 278–286 (2012).
Xue, W. et al. Nature 445, 656–660 (2007).
Bergsbaken, T., Fink, S. L. & Cookson, B. T. Nat. Rev. Microbiol. 7, 99–109 (2009).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Hoare, M., Narita, M. Transmitting senescence to the cell neighbourhood. Nat Cell Biol 15, 887–889 (2013). https://doi.org/10.1038/ncb2811
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb2811