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Regulation of cellular homeostasis by galectins

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Abstract

Members of the galectin family are presently known to participate in cellular homeostasis by modulating cell growth, controlling cell cycle progression, and inducing or inhibiting apoptosis. Both intracellular and extracellular activities of galectins have been described, with the former typically independent of lectin activity, and the latter mediated by lectin activity. Galectin-1 and -3 are recognized as activators and inducers of cell stasis in extracellular capacities. Galectin-1, -7, -8, -9 and -12 are characterized as promoters or inducers of apoptosis, while galectin-3 is demonstrated as an inhibitor of apoptosis intracellularly. Localization studies of galectins have established that these proteins can segregate into multiple intracellular compartments, and the preference for segregation is dependent on the status of the cell. Localization would, therefore, likely correspond to compartmental function. While galectin-1 and -3 have been the most abundantly expressed and extensively studied, and therefore, the members best understood, expanding interest in galectins has resulted in description of new members that display more restricted expression patterns, suggesting more specific activity. Nevertheless, as demonstrated for many members, it appears that a major feature of the galectin family is the homeostatic regulation of cells. Published in 2004.

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References

  1. Letunic I, Goodstadt L, Dickens NJ, Doerks T, Schultz J, Mott R, Ciccarelli F, Copley RR, Ponting CP, Bork P, Recent improvements to theSMART domain-based sequence annotation resource, Nucleic Acids Res 30, 242-4 (2002).

    Google Scholar 

  2. Ogden AT, Nunes I, Ko K, Wu SJ, Hines CS, Wang AF, Hedge RS, Lang RA, GRIFIN, a novel lens-specific protein related to the galectin family, J Biol Chem 273, 28889-96 (1998).

    Google Scholar 

  3. Sanford GL, Harris-Hooker S, Stimulation of vascular cell proliferation by β-galactoside specfic lectins, FASEB J 4, 2912-8 (1990).

    Google Scholar 

  4. Yamaoka K, Ingendoh A, Tsubuki S, Nagai Y, Sanai Y, Structural and functional characterization of a novel tumor-derived rat galectin-1 having transforming growth factor (TGF) activity: The relationship between intramolecular disulfide bridges and TGF activity, J Biochem (Tokyo) 119, 878-86 (1996).

    Google Scholar 

  5. Horie H, Inagaki Y, Sohma Y, Nozawa R, Okawa K, Hasegawa M, Muramatsu N, Kawano H, Horie M, Koyama H, Sakai I, Takeshita K, Kowada Y, Takano M, Kadoya T, Galectin-1 regulates initial axonal growth in peripheral nerves after axotomy, J Neurosci 19, 9964-74 (1999).

    Google Scholar 

  6. Kopitz J, Von Reitzenstein C, Burchert M, Cantz M, Gabius HJ, Galectin-1 is a major receptor for ganglioside GM1, a product of the growth-controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture, J Biol Chem 273, 11205-11 (1998).

    Google Scholar 

  7. Wells V, Mallucci L, Identification of an autocrine negative growth factor: Mouse β-galactoside-binding protein is a cytostatic factor and cell growth regulator, Cell 64, 91-7 (1991).

    Google Scholar 

  8. Rabinovich GA, Modesti NM, Castagna LF, Landa CA, Riera CM, Sotomayor CE, Specific inhibition of lymphocyte proliferation and induction of apoptosis by CLL-I, a β-galactoside-binding lectin, J Biochem (Tokyo) 122, 365-73 (1997).

    Google Scholar 

  9. Allione A, Wells V, Forni G, Mallucci L, Novelli F, β-galactosidebinding protein (βGBP) alters the cell cycle, up-regulates expression of the α-and β-chains of the IFN-gamma receptor, and triggers IFN-gamma-mediated apoptosis of activated human T lymphocytes, J Immunol 161, 2114-9 (1998).

    Google Scholar 

  10. Blaser C, Kaufmann M, M¨uller C, Zimmermann C, Wells V, Mallucci L, Pircher H, β-galactoside binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells, Eur J Immunol 28, 2311-9 (1998).

    Google Scholar 

  11. Yamaoka K, Mishima K, Nagashima Y, Asai A, Sanai Y, Kirino T, Expression of galectin-1 mRNA correlates with the malignant potential of human gliomas and expression of antisense galectin-1 inhibits the growth of 9 glioma cells, J Neurosci Res 59, 722-30 (2000).

    Google Scholar 

  12. Adams L, Scott GK, Weinberg CS, Biphasic modulation of cell growth by recombinant human galectin-1, Biochim Biophys Acta Mol Cell Res 1312, 137-44 (1996).

    Google Scholar 

  13. Perillo NL, Pace KE, Seilhamer JJ, Baum LG, Apoptosis of T cells mediated by galectin-1, Nature 378, 736-9 (1995).

    Google Scholar 

  14. Perillo NL, Uittenbogaart CH, Nguyen JT, Baum LG, Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes, J Exp Med 185, 1851-8 (1997).

    Google Scholar 

  15. Rabinovich GA, Iglesias MM, Modesti NM, Castagna LF, Wolfenstein-Todel C, Riera CM, Sotomayor CE, Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: Biochemical and functional characterization, J Immunol 160, 4831-40 (1998).

    Google Scholar 

  16. Vespa GNR, Lewis LA, Kozak KR, Moran M, Nguyen JT, Baum LG, Miceli MC, Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation, J Immunol 162, 799-806 (1999).

    Google Scholar 

  17. Wells V, Davies D, Mallucci L, Cell cycle arrest and induction of apoptosis by beta galactoside binding protein (beta GBP) in human mammary cancer cells.Apotential newapproach to cancer control, Eur J Cancer 35, 978-83 (1999).

    Google Scholar 

  18. Ellerhorst J, Nguyen T, Cooper DN, Estrov Y, Lotan D, Lotan R, Induction of differentiation and apoptosis in the prostate cancer cell line LNCaP by sodium butyrate and galectin-1, Int J Oncol 14, 225-32 (1999).

    Google Scholar 

  19. Pace KE, Lee C, Stewart PL, Baum LG, Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1, J Immunol 163, 3801-11 (1999).

    Google Scholar 

  20. Walzel H, Schulz U, Neels P, Brock J, Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45, Immunol Lett 67, 193-202 (1999).

    Google Scholar 

  21. Nguyen JT, Evans DP, Galvan M, Pace KE, Leitenberg D, Bui TN, Baum LG, CD45 modulates galectin-1-induced T cell death: Regulation by expression of core 2 O-glycans, J Immunol 167, 5697-707 (2001).

    Google Scholar 

  22. Fajka-Boja R, Szemes M, Ion G, Legradi A, Caron M, Monostori E, Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not mediate its apoptotic signal in T cell lines, Immunol Lett 82, 149-54 (2002).

    Google Scholar 

  23. Novelli F, Allione A, Wells V, Forni G, Malluci L, Negative cell cycle control of human T cells by beta-galactoside binding protein (beta GBP): Induction of programmed cell death in leukaemic cells, J Cell Physiol 178, 102-8 (1999).

    Google Scholar 

  24. Cooper DNW, Massa SM, Barondes SH, Endogenous muscle lectin inhibits myoblast adhesion to laminin, J Cell Biol 115, 1437-48 (1991).

    Google Scholar 

  25. Gu M, Wang W, Song WK, Cooper DNW, Kaufman SJ, Selective modulation of the interaction of α7β1 integrin with fibronectin and laminin by L-14 lectin during skeletal muscle differentiation, J Cell Sci 107, 175-81 (1994).

    Google Scholar 

  26. Rabinovich GA, Ariel A, Hershkovitz R, Hirabayashi J, Kasai KI, Lider O, Specific inhibition of T-cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin-1, Immunology 97, 100-6 (1999).

    Google Scholar 

  27. Wells V, Davies D, Mallucci L, Cell cycle arrest and induction of apoptosis by β galactoside binding protein (βGBP) in human mammary cancer cellsApotential newapproach to cancer control, Eur J Cancer 35, 978-83 (1999).

    Google Scholar 

  28. Paz A, Haklai R, Elad-Sfadia G, Ballan E, Kloog Y, Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation, Oncogene 20, 7486-93 (2001).

    Google Scholar 

  29. Elad-Sfadia G, Haklai R, Ballan E, Gabius HJ, Kloog Y, Galectin-1 augments Ras activation and diverts Ras signals to Raf-1 at the expense of phosphoinositide 3-kinase, J Biol Chem 277, 37169-75 (2002).

    Google Scholar 

  30. Prior IA, Muncke C, Parton RG, Hancock JF, Direct visualization of Ras proteins in spatially distinct cell surface microdomains, J Cell Biol 160, 165-70 (2003).

    Google Scholar 

  31. Inohara H, Akahani S, Raz A, Galectin-3 stimulates cell proliferation, Exp Cell Res 245, 294-302 (1998).

    Google Scholar 

  32. Sasaki S, Bao Q, Hughes RC, Galectin-3 modulates rat mesangial cell proliferation and matrix synthesis during experimental glomerulonephritis induced by anti-Thy1.1 antibodies, J Pathol 187, 481-9 (1999).

    Google Scholar 

  33. Pesheva P, Kuklinski S, Schmitz B, Probstmeier R, Galectin-3 promotes neural cell adhesion and neurite growth, J Neurosci Res 54, 639-54 (1998).

    Google Scholar 

  34. Nangia-Makker P, Honjo Y, Sarvis R, Akahani S, Hogan V, Pienta KJ, Raz A, Galectin-3 induces endothetial cell morphogenesis and angiogenesis, Am J Pathol 156, 899-909 (2000).

    Google Scholar 

  35. Bao Q, Hughes RC, Galectin-3 and polarized growth within collagen gels of wild-type and ricin-resistant MDCK renal epithelial cells, Glycobiology 9, 489-95 (1999).

    Google Scholar 

  36. Krugluger W, Frigeri LG, Lucas T, Schmer M, Forster O, Liu F-T, Boltz-Nitulescu G, Galectin-3 inhibits granulocytemacrophage colony-stimulating factor (GM-CSF)-driven rat bone marrow cell proliferation and GM-CSF-induced gene transcription, Immunobiology 197, 97-109 (1997).

    Google Scholar 

  37. Yang R-Y, Hsu DK, Liu F-T, Expression of galectin-3 modulates T cell growth and apoptosis, Proc Natl Acad Sci USA 93, 6737-42 (1996).

    Google Scholar 

  38. Van den Brule FA, Bellahcene A, Jackers F, Liu F-T, Sobel ME, Castronovo V, Antisense galectin-3 alters thymidine incorporation in human MDA-MB435 breast cancer cells, Int J Oncology 11, 261-4 (1997).

    Google Scholar 

  39. Honjo Y, Nangia-Makker P, Inohara H, Raz A, Down-regulation of galectin-3 suppresses tumorigenicity of human breast carcinoma cells, Clin Cancer Res 7, 661-8 (2001).

    Google Scholar 

  40. Joo HG, Goedegebuure PS, Sadanaga N, Nagoshi M, von Bernstorff W, Eberlein TJ, Expression and function of galectin-3, a betagalactoside-binding protein in activated T lymphocytes, J Leukoc Biol 69, 555-64 (2001).

    Google Scholar 

  41. Yoshii T, Inohara H, Takenaka Y, Honjo Y, Akahani S, Nomura T, Raz A, Kubo T, Galectin-3 maintains the transformed phenotype of thyroid papillary carcinoma cells, Int J Oncol 18, 787-92 (2001).

    Google Scholar 

  42. Ellerhorst JA, Stephens LC, Nguyen T, Xu XC, Effects of galectin-3 expression on growth and tumorigenicity of the prostate cancer cell line LNCaP, Prostate 50, 64-70 (2002).

    Google Scholar 

  43. Paron I, Scaloni A, Pines A, Bachi A, Liu FT, Puppin C, Pandolfi M, Ledda L, Di Loreto C, Damante G, Tell G, Nuclear localization of Galectin-3 in transformed thyroid cells:Arole in transcriptional regulation, Biochem Biophys Res Commun 302, 545-53 (2003).

    Google Scholar 

  44. Akahani S, Nangia-Makker P, Inohara H, Kim HRC, Raz A, Galectin-3: A novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family, Cancer Res 57, 5272-6 (1997).

    Google Scholar 

  45. Lin HM, Moon BK, Yu F, Kim HR, Galectin-3 mediates genisteininduced G(2)/M arrest and inhibits apoptosis, Carcinogen 21, 1941-5 (2001).

    Google Scholar 

  46. Kim HRC, Lin HM, Biliran H, Raz A, Cell cycle arrest and inhibition of anoikis by galectin-3 in human breast epithelial cells, Cancer Res 59, 4148-54 (1999).

    Google Scholar 

  47. Moon BK, Lee YJ, Battle P, Jessup JM, Raz A, Kim HR, Galectin-3 protects human breast carcinoma cells against nitric oxide-induced apoptosis: Implication of galectin-3 function during metastasis, Am J Pathol 159, 1055-60 (2001).

    Google Scholar 

  48. Mataresse P, Fusco O, Tinari N, Natoli C, Liu F-T, Semeraro ML, Malorni W, Iacobelli S, Galectin-3 overexpression protects from apoptosis by improving cell adhesion properties, Int J Cancer 85, 545-54 (2000).

    Google Scholar 

  49. Hsu DK, Yang R-Y, Yu L, Pan Z, Salomon DR, Fung-Leung W-P, Liu F-T, Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses, Amer J Pathol 156, 1073-83 (2000).

    Google Scholar 

  50. Colnot C, Sidhu SS, Balmain N, Poirier F, Uncoupling of chondrocyte death and vascular invasion in mouse galectin 3 null mutant bones, Dev Biol 229, 203-14, 2001.

    Google Scholar 

  51. Yu F, Finley RL Jr, Raz A, Kim HR, Galectin-3 Translocates to the Perinuclear Membranes and Inhibits Cytochrome c Release from the Mitochondria. A role for synexin in galectin-3 translocation, J Biol Chem 277, 15819-27 (2002).

    Google Scholar 

  52. Yoshii T, Fukumori T, Honjo Y, Inohara H, Kim HR, Raz A, Galectin-3 phosphorylation is required for its anti-apoptotic function and cell cycle arrest, J Biol Chem 277, 6852-7 (2002).

    Google Scholar 

  53. Sano H, Hsu DK, Apgar JR, Yu L, Sharma BB, Kuwabara I, Izui S, Liu F-T, Critical role of galectin-3 in phagocytosis by macrophages, J Clin Invest 112, 389-97 (2003).

    Google Scholar 

  54. Sato S, Hughes RC, Binding specificity of a baby hamster kidney lectin for H type I and II chains, polylactosamine glycans, and appropriately glycosylated forms of laminin and fibronectin, J Biol Chem 267, 6983-90 (1992).

    Google Scholar 

  55. Ochieng J, Leite-Browning ML, Warfield P, Regulation of cellular adhesion to extracellular matrix proteins by galectin-3, Biochem Biophys Res Commun 246, 788-91 (1998).

    Google Scholar 

  56. Moutsatsos IK, Wade M, Schindler M, Wang JL, Endogenous lectins from cultured cells: Nuclear localization of carbohydratebinding protein 35 in proliferating 3T3 fibroblasts, Proc Natl Acad Sci USA 84, 6452-6 (1987).

    Google Scholar 

  57. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B, A model for p53-induced apoptosis, Nature 389, 300-5 (1997).

    Google Scholar 

  58. Bernerd F, Sarasin A, Magnaldo T, Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes, Proc Natl Acad Sci USA 96, 11329-34 (1999).

    Google Scholar 

  59. Kuwabara I, Kuwabara Y, Yang RY, Schuler M, Green DR, Zuraw BL, Hsu DK, Liu FT, Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release, J Biol Chem 277, 3487-97 (2002).

    Google Scholar 

  60. Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y, Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis, J Cell Sci 113(Pt 13), 2385-97 (2000).

    Google Scholar 

  61. Wada J, Ota K, Kumar A, Wallner EI, Kanwar YS, Developmental regulation, expression, and apoptotic potential of galectin-9, a β-galactoside binding lectin, J Clin Invest 99, 2452-61 (1997).

    Google Scholar 

  62. Saita N, Goto E, Yamamoto T, Cho I, Tsumori K, Kohrogi H, Maruo K, Ono T, Takeya M, Kashio Y, Nakamura K, Hirashima M, Association of galectin-9 with eosinophil apoptosis, Int Arch Allergy Immunol 128, 42-50 (2002).

    Google Scholar 

  63. Yang R-Y, Hsu, DK, Yu L, Ni J, Liu FT, Cell cycle regulation by galectin-12, a new member of the galectin superfamily, J Biol Chem 276, 2025 2-60, 2001.

    Google Scholar 

  64. Hotta K, Funahashi T, Matsukawa Y, Takahashi M, Nishizawa H, Kishida K, Matsuda M, Kuriyama H, Kihara S, Nakamura T, Tochino Y, Bodkin NL, Hansen BC, Matsuzawa Y, Galectin-12, an adipose-expressed galectin-like molecule possessing apoptosisinducing activity, J Biol Chem 276, 34089-97 (2001).

    Google Scholar 

  65. Chen C-YA, Shyu A-B, Au-rich elements: Characterization and importance in mRNA degradation, Trends Biochem Sci 20, 465-70 (1995).

    Google Scholar 

  66. Laroia G, Cuesta R, Brewer G, Schneider RJ, Control of mRNA decay by heat shock-ubiquitin-proteasome pathway, Science 284, 499-502 (1999).

    Google Scholar 

  67. Hughes RC, Secretion of the galectin family of mammalian carbohydrate-binding proteins, Biochim Biophys Acta 1473, 172-85 (1999).

    Google Scholar 

  68. Thery C, Boussac M, Veron P, Ricciardi-Castagnoli P, Raposo G, Garin J, Amigorena S, Proteomic analysis of dendritic cellderived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles, J Immunol 166, 7309-18 (2001).

    Google Scholar 

  69. Inagaki Y, Sohma Y, Horie H, Nozawa R, Kadoya T, Oxidized galectin-1 promotes axonal regeneration in peripheral nerves but does not possess lectin properties, Eur J Biochem 267, 2955-64 (2000).

    Google Scholar 

  70. Golladay SA, Park SH, Aust AE, Efflux of reduced glutathione after exposure of human lung epithelial cells to crocidolite asbestos, Environ Health Perspect 105(Suppl 5), 1273-7 (1997).

    Google Scholar 

  71. Goletz S, Hanisch F-G, Karsten U, Novel ?GalNAc containing glycans on cytokeratins are recognized in vitro by galectins with type II carbohydrate recognition domains, J Cell Sci 110, 1585-96 (1997).

    Google Scholar 

  72. Sève A-P, Felin M, Doyennette-Moyne M-A, Sahraoui T, Aubery M, Hubert J, Evidence for a lactose-mediated association between two nuclear carbohydrate-binding proteins, Glycobiology 3, 23-30 (1993).

    Google Scholar 

  73. Yang RY, Hill PN, Hsu DK, Liu FT, Role of the carboxyl-terminal lectin domain in self-association of galectin-3, Biochemistry 37, 4086-92 (1998).

    Google Scholar 

  74. Vyakarnam A, Dagher SF, Wang JL, Patterson RJ, Evidence for a role for galectin-1 in pre-mRNA splicing, Mol Cell Biol 17, 4730-7 (1997).

    Google Scholar 

  75. Dagher SF, Wang JL, Patterson RJ, Identification of galectin-3 as a factor in pre-mRNA splicing, Proc Natl Acad Sci USA 92, 1213-7 (1995).

    Google Scholar 

  76. Mazurek N, Conklin J, Byrd JC, Raz A, Bresalier RS, Phosphorylation of the beta-Galactoside-binding Protein Galectin-3 Modulates Binding to Its Ligands, J Biol Chem 275, 36311-5 (2001).

    Google Scholar 

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  1. Department of Dermatology, University of California-Davis, School of Medicine, Sacramento, CA, 95817, USA

    Daniel K. Hsu & Fu-Tong Liu

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Hsu, D.K., Liu, FT. Regulation of cellular homeostasis by galectins. Glycoconj J 19, 507–515 (2002). https://doi.org/10.1023/B:GLYC.0000014080.95829.52

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