[go: up one dir, main page]
More Web Proxy on the site http://driver.im/ Skip to main content

Advertisement

Springer Nature Link
Log in

Different Hepatitis C Virus Infection Statuses Show a Significant Risk of Developing Type 2 Diabetes Mellitus: A Network Meta-Analysis

  • Review
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Background

The role of hepatitis C virus (HCV) infection statuses in the development of type 2 diabetes mellitus (T2DM) has not been completely understood.

Aim

To evaluate the prevalence of T2DM in patients with different HCV infection statuses.

Methods

We conducted a systematic study on T2DM risk in five types of individuals with different HCV infection statuses: non-HCV controls, HCV-cleared patients, chronic HCV patients without cirrhosis, patients with HCV cirrhosis and patients with decompensated HCV cirrhosis. Studies published from 2010 to 2019 were selected. Both pairwise and network meta-analyses were employed to compare the T2DM risk among patients with different HCV infection statuses.

Results

The pairwise meta-analysis showed that non-HCV (OR = 0.60, 95% CI [0.47–0.78]) had a lower risk of T2DM compared with CHC, while cirrhosis had a significant higher risk (OR = 1.90, 95% CI [1.60–2.26]). Network meta-analysis further demonstrated patients with HCV infection were at a significantly higher risk of T2DM than those without HCV infection or with HCV clearance, while decompensated cirrhosis had a significant higher T2DM risk than non-HCV (OR = 3.84, 95% CI [2.01–7.34]), patients with HCV clearance (OR = 3.17, 95% CI [1.49–6.73]), and CHC patients (OR = 2.21, 95% CI [1.24–3.94]).

Conclusions

HCV infection is a significant risk factor for developing T2DM. CHC, cirrhosis, and decompensated cirrhosis contribute to an increasingly greater risk of T2DM, but HCV clearance spontaneously or through clinical treatment may immediately reduce the risk of the onset and development of T2DM.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
£29.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (United Kingdom)

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

Abbreviations

HCV:

Hepatitis C virus

T2DM:

Type 2 diabetes mellitus

CHC:

Chronic hepatitis C

OR:

Odds ratio

CIs:

Confidence intervals

IR:

Insulin resistance

PRISMA:

Preferred Reporting Items for Systematic Reviews and Meta-Analyses

NOS:

Newcastle–Ottawa Quality Assessment Scale

AHRQ:

Agency for Healthcare Research and Quality

NMA:

Network meta-analysis

SUCRA:

Surface under the cumulative ranking curve

ROR:

Ratio of two odds ratios

HD:

Hepatogenous diabetes

SVR:

Sustained virological responses

DAAs:

Direct-acting antivirals

OGTT:

Oral glucose tolerance test

VS:

Versus

References

  1. World Health Organization. Global hepatitis report 2017. https://www.who.int/hepatitis/publications/global-hepatitis-report2017/en/. Accessed Sep 30, 2019.

  2. Gordon SC, Pockros PJ, Terrault NA, et al. Impact of disease severity on healthcare costs in patients with chronic hepatitis C (CHC) virus infection. Hepatology. 2012;56:1651–1660.

    Article  PubMed  Google Scholar 

  3. Micallef JM, Kaldor JM, Dore GJ. Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studies. J Viral Hepat. 2006;13:34–41.

    Article  CAS  PubMed  Google Scholar 

  4. Freeman AJ, Dore GJ, Law MG, et al. Estimating progression to cirrhosis in chronic hepatitis C virus infection. Hepatology. 2001;34:809–816.

    Article  CAS  PubMed  Google Scholar 

  5. Chen SL, Morgan TR. The natural history of hepatitis C virus (HCV) infection. Int J Med Sci. 2006;3:47–52.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Younossi Z, Park H, Henry L, Adeyemi A, Stepanova M. Extrahepatic manifestations of hepatitis C: a meta-analysis of prevalence, quality of life, and economic burden. Gastroenterology. 2016;150:1599–1608.

    Article  PubMed  Google Scholar 

  7. Fallahi P, Ferrari SM, Vita R, Benvenga S, Antonelli A. The role of human parvovirus b19 and hepatitis C virus in the development of thyroid disorders. Rev Endocr Metab Disord. 2016;17:529–535.

    Article  CAS  PubMed  Google Scholar 

  8. Shepard CW, Finelli L, Alter MJ. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis. 2005;5:558–567.

    Article  PubMed  Google Scholar 

  9. White DL, Ratziu V, El-Serag HB. Hepatitis C infection and risk of diabetes: a systematic review and meta-analysis. J Hepatol. 2008;49:831–844.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Antonelli A, Ferrari SM, Giuggioli D, et al. Hepatitis C virus infection and type 1 and type 2 diabetes mellitus. World J Diabetes. 2014;5:586–600.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Fabiani S, Fallahi P, Ferrari SM, Miccoli M, Antonelli A. Hepatitis C virus infection and development of type 2 diabetes mellitus: systematic review and meta-analysis of the literature. Rev Endocr Metab Disord. 2018;19:405–420.

    Article  PubMed  Google Scholar 

  12. Ruhl CE, Menke A, Cowie CC, Everhart JE. Relationship of hepatitis C virus infection with diabetes in the U.S. Population. Hepatology. 2014;60:1139–1149.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Wells GA, Shea BJ, O’Connell D, et al. The Newcastle–Ottawa scale (NOS) for assessing the quality of non-randomized studies in meta-analysis. Ottawa: Ottawa Health Research Institute; 2012.

    Google Scholar 

  14. West S, King V, Carey TS, et al. Systems to rate the strength of scientific evidence. United States, US: Evidence Report/Technology assessment; 2002.

    Google Scholar 

  15. Salanti G, Ades AE, Ioannidis JP. Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial. J Clin Epidemiol. 2011;64:163–171.

    Article  PubMed  Google Scholar 

  16. Bucher HC, Guyatt GH, Griffith LE, Walter SD. The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials. J Clin Epidemiol. 1997;50:683–691.

    Article  CAS  PubMed  Google Scholar 

  17. Ghany MG, Kim HY, Stoddard A, et al. Predicting clinical outcomes using baseline and follow-up laboratory data from the hepatitis C long-term treatment against cirrhosis trial. Hepatology. 2011;54:1527–1537.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Nischalke HD, Berger C, Luda C, et al. The PNPLA3 rs738409 148 M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis. PLoS ONE. 2011;6:e27087.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Rao GA, Pandya PK. Statin therapy improves sustained virologic response among diabetic patients with chronic hepatitis C. Gastroenterology. 2011;140:144–152.

    Article  CAS  PubMed  Google Scholar 

  20. Stepanova M, Aquino R, Alsheddi A, Gupta R, Fang Y, Younossi Z. Clinical predictors of fibrosis in patients with chronic liver disease. Aliment Pharmacol Therap. 2010;31:1085–1094.

    CAS  Google Scholar 

  21. Stepanova M, Rafiq N, Younossi ZM. Components of metabolic syndrome are independent predictors of mortality in patients with chronic liver disease: a population-based study. Gut. 2010;59:1410–1415.

    Article  PubMed  Google Scholar 

  22. Huang YW, Yang SS, Fu SC, et al. Increased risk of cirrhosis and its decompensation in chronic hepatitis C patients with new-onset diabetes: a nationwide cohort study. Hepatology. 2014;60:807–814.

    Article  PubMed  Google Scholar 

  23. Trepo E, Pradat P, Potthoff A, et al. Impact of patatin-like phospholipase-3 (rs738409 C > G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C. Hepatology. 2011;54:60–69.

    Article  CAS  PubMed  Google Scholar 

  24. Younossi ZM, Stepanova M, Nader F, Younossi Z, Elsheikh E. Associations of chronic hepatitis C with metabolic and cardiac outcomes. Aliment Pharmacol Therap. 2013;37:647–652.

    Article  CAS  Google Scholar 

  25. Giordanino C, Ceretto S, Bo S, et al. Type 2 diabetes mellitus and chronic hepatitis C: which is worse? Results of a long-term retrospective cohort study. Dig Liver Dis. 2012;44:406–412.

    Article  PubMed  Google Scholar 

  26. Afsari A, Lee E, Shokrani B, et al. Clinical and pathological risk factors associated with liver fibrosis and steatosis in African-Americans with chronic hepatitis C. Dig Dis Sci. 2017;62:2159–2165.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Cancienne JM, Dempsey IJ, Holzgrefe RE, Brockmeier SF, Werner BC. Is hepatitis C infection associated with a higher risk of complications after total shoulder arthroplasty? Clin Orthop Relat Res. 2016;474:2664–2669.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Garvey P, Murphy N, Flanagan P, et al. Disease outcomes in a cohort of women in Ireland infected by hepatitis C-contaminated anti-D immunoglobulin during 1970s. J Hepatol. 2017;67:1140–1147.

    Article  PubMed  Google Scholar 

  29. Schnier C, Wild S, Kurdi Z, Povey C, Goldberg DJ, Hutchinson SJ. Matched population-based study examining the risk of type 2 diabetes in people with and without diagnosed hepatitis C virus infection. J Viral Hepat. 2016;23:596–605.

    Article  CAS  PubMed  Google Scholar 

  30. Saeed MJ, Olsen MA, Powderly WG, Presti RM. Diabetes mellitus is associated with higher risk of developing decompensated cirrhosis in chronic hepatitis C patients. J Clin Gastroenterol. 2017;51:70–76.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Taneja S, Tohra S, Duseja A, Dhiman RK, Chawla YK. Noninvasive assessment of liver fibrosis by transient elastography and fib4/apri for prediction of treatment response in chronic hepatitis C-an experience from a tertiary care hospital. J Clin Exp Hepatol. 2016;6:282–290.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Turner BJ, Wang CP, Melhado TV, et al. Significant increase in risk of fibrosis or cirrhosis at time of HCV diagnosis for hispanics with diabetes and obesity compared with other ethnic groups. Clin Gastroenterol Hepatol. 2019;17:1356–1363.

    Article  PubMed  Google Scholar 

  33. Corey KE, Zheng H, Mendez-Navarro J, et al. Serum vitamin D levels are not predictive of the progression of chronic liver disease in hepatitis C patients with advanced fibrosis. PLoS ONE. 2012;7:e27144.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Elhawary EI, Mahmoud GF, El-Daly MA, Mekky FA, Esmat GG, Abdel-Hamid M. Association of HCV with diabetes mellitus: an Egyptian case-control study. Virol J. 2011;8:367.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Li X, Gao Y, Xu H, Hou J, Gao P. Diabetes mellitus is a significant risk factor for the development of liver cirrhosis in chronic hepatitis C patients. Sci Rep. 2017;7:9087.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  36. Abdelaziz SB, Galal YS, Sedrak AS, Shaheen DS. Association of hepatitis C virus infection and type 2 diabetes in Egypt: a hospital-based study. J Diabetes Mellitus. 2016;6:77–89.

    Article  Google Scholar 

  37. Cuadros DF, Miller FD, Nagelkerke N, Abu-Raddad LJ. Association between HCV infection and diabetes type 2 in Egypt: is it time to split up? Ann Epidemiol. 2015;25:918–923.

    Article  PubMed  Google Scholar 

  38. Hung CH, Lee CM, Wang JH, et al. Impact of diabetes mellitus on incidence of hepatocellular carcinoma in chronic hepatitis C patients treated with interferon-based antiviral therapy. Int J Cancer. 2011;128:2344–2352.

    Article  CAS  PubMed  Google Scholar 

  39. Kumar A, Gupta V, Sharma P, Bansal N, Singla V, Arora A. Association of overt diabetes mellitus with the non-CC but not the CC genotype of interleukin-28B in hepatitis C virus infected patients. J Clin Transl Hepatol. 2016;4:26–31.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Mostafa A, Mohamed MK, Saeed M, et al. Hepatitis C infection and clearance: impact on atherosclerosis and cardiometabolic risk factors. Gut. 2010;59:1135–1140.

    Article  CAS  PubMed  Google Scholar 

  41. Rouabhia S, Malek R, Bounecer H, et al. Prevalence of type 2 diabetes in Algerian patients with hepatitis C virus infection. World J Gastroenterol. 2010;16:3427–3431.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Naing C, Mak JW, Ahmed SI, Maung M. Relationship between hepatitis C virus infection and type 2 diabetes mellitus: meta-analysis. World J Gastroenterol. 2012;18:1642–1651.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Adinolfi LE, Nevola R, Guerrera B, et al. Hepatitis C virus clearance by direct-acting antiviral treatments and impact on insulin resistance in chronic hepatitis C patients. J Gastroenterol Hepatol. 2018;33:1379–1382.

    Article  CAS  PubMed  Google Scholar 

  44. Drazilova S, Gazda J, Janicko M, Jarcuska P. Chronic hepatitis C association with diabetes mellitus and cardiovascular risk in the era of DAA therapy. Can J Gastroenterol Hepatol. 2018;2018:6150861.

    PubMed  PubMed Central  Google Scholar 

  45. Arase Y, Suzuki F, Suzuki Y, et al. Sustained virological response reduces incidence of onset of type 2 diabetes in chronic hepatitis C. Hepatology. 2009;49:739–744.

    Article  CAS  PubMed  Google Scholar 

  46. Cacoub P, Desbois AC, Comarmond C, Saadoun D. Impact of sustained virological response on the extrahepatic manifestations of chronic hepatitis C: a meta-analysis. Gut. 2018;67:2025–2034.

    Article  CAS  PubMed  Google Scholar 

  47. Jeon HK, Kim MY, Baik SK, et al. Hepatogenous diabetes in cirrhosis is related to portal pressure and variceal hemorrhage. Dig Dis Sci. 2013;58:3335–3341.

    Article  PubMed  Google Scholar 

Download references

Funding

This work was supported by the Postgraduate Research & Practice Innovation Program of Jiangsu Province [Grant Number KYCX19_2084] and the Undergraduate Training Programs for Innovation and Entrepreneurship of Nantong University [Grant Number 2019152].

Author information

Author notes

  1. Ying Chen and Hanzhen Ji have contributed equally to this work.

Authors and Affiliations

  1. Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, 9 Se-Yuan Road, Nantong, 226019, Jiangsu, China

    Ying Chen, Jianguo Shao, Yulong Jia, Qi Bao, Jianan Zhu & Yi Shen

  2. Centre for Liver Diseases, Nantong Third People’s Hospital, Nantong University, Nantong, China

    Hanzhen Ji & Jianguo Shao

  3. Research Centre for Public Health, School of Medicine, Tsinghua University, Beijing, China

    Lei Zhang

  4. Melbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia

    Lei Zhang

  5. Central Clinical School, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Australia

    Lei Zhang

  6. School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia

    Lei Zhang

Authors
  1. Ying Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hanzhen Ji
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jianguo Shao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yulong Jia
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Qi Bao
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jianan Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Lei Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yi Shen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yi Shen.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval

Not required.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (RAR 564 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, Y., Ji, H., Shao, J. et al. Different Hepatitis C Virus Infection Statuses Show a Significant Risk of Developing Type 2 Diabetes Mellitus: A Network Meta-Analysis. Dig Dis Sci 65, 1940–1950 (2020). https://doi.org/10.1007/s10620-019-05918-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-019-05918-7

Keywords

Search

Navigation