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Increased Expression of Long Pentraxin PTX3 in Inflammatory Bowel Diseases

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Abstract

The aims of this study were to investigate the expression of pentraxin-3 in inflamed gastrointestinal tissue in patients with inflammatory bowel diseases and to elucidate the usefulness of plasma pentraxin-3 level as an inflammation marker in patients with inflammatory bowel diseases. Pentraxin-3 immunoreactivity was found in infiltrating neutrophils and vessels in the inflamed gut. Plasma pentraxin-3 concentration in patients with active inflammatory bowel diseases was significantly higher than that of normal subjects and patients with inactive inflammatory bowel diseases. Significant positive correlations of clinical disease activity with plasma pentraxin-3 concentration and serum CRP concentration were found in patients with inflammatory bowel diseases. Pentraxin-3 is directly produced from the inflamed gut in inflammatory bowel diseases. In conclusion, plasma pentraxin-3 concentration is a useful marker for understanding the disease activity in patients with inflammatory bowel diseases.

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Tsujido-machi, Kawagoe, Saitama, 359-8513, Japan

    Shingo Kato, Mitsuko Ochiai, Tomoya Sakurada, Shino Ohno & Koji Yakabi

  2. Perseus Proteomics Inc., Tokyo, Japan

    Kyoko Miyamoto & Mina Sagara

  3. Department of Developmental Anatomy and Regenerative Biology, National Defense Medical College, Saitama, Japan

    Masataka Ito, Kyoko Takeuchi & Junko Imaki

  4. Department of Internal Medicine, National Defense Medical College, Saitama, Japan

    Kazuro Itoh

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  1. Shingo Kato
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Correspondence to Shingo Kato.

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Kato, S., Ochiai, M., Sakurada, T. et al. Increased Expression of Long Pentraxin PTX3 in Inflammatory Bowel Diseases. Dig Dis Sci 53, 1910–1916 (2008). https://doi.org/10.1007/s10620-007-0075-z

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  • DOI: https://doi.org/10.1007/s10620-007-0075-z

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