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Nanoparticle dermal absorption and toxicity: a review of the literature

  • Review Article
  • Published:
International Archives of Occupational and Environmental Health Aims and scope Submit manuscript

Abstract

Introduction

Nanotechnologies are among the fastest growing areas of scientific research and have important applications in a wide variety of fields. The data suggest that in the future workers and consumers exposed to nanoparticles will significantly increase.

Dermal absorption and toxicity of nanoparticles

At now there are gaps in understanding about the human and environmental risk that manufactured nanoparticles pose for occupational exposed people and for consumers. There is a need for assessing the health and environmental impacts, the nanoparticles life cycle, the human exposure routes, the behavior of nanoparticles in the body, and the risk for workers. Possible routes of entry into the body include inhalation, absorption through the skin or digestive tract, injection, and absorption or implantation for drugs delivery systems. In particular, dermal absorption and skin penetration of nanoparticles needs a better evaluation because few and contradictory data are present in the literature, mainly on titanium dioxide.

Conclusions

There are limited data on carbon-based nanoparticles and very few data on other metal nanoparticles increasingly used in industry. The article reviews the literature on the percutaneous absorption of nanoparticles and their effect on skin.

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Authors and Affiliations

  1. Dipartimento di Scienze Chimiche, Università di Trieste, Via L. Giorgieri 1, 34127, Trieste, Italy

    Matteo Crosera & Gianpiero Adami

  2. UCO Medicina del Lavoro, Dipartimento di Scienze di Medicina Pubblica, Università di Trieste, Trieste, Italy

    Massimo Bovenzi & Francesca Filon Larese

  3. Laboratorio di Tossicologia Industriale, CTO, Università di Torino, Torino, Italy

    Giovanni Maina

  4. Dipartimento di Scienze della Vita, Università di Trieste, Trieste, Italy

    Caterina Zanette & Chiara Florio

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  1. Matteo Crosera
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Correspondence to Matteo Crosera.

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Crosera, M., Bovenzi, M., Maina, G. et al. Nanoparticle dermal absorption and toxicity: a review of the literature. Int Arch Occup Environ Health 82, 1043–1055 (2009). https://doi.org/10.1007/s00420-009-0458-x

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  • DOI: https://doi.org/10.1007/s00420-009-0458-x

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