[go: up one dir, main page]
More Web Proxy on the site http://driver.im/ Skip to main content
Springer Nature Link
Log in

Supplementation with selenium and human immune cell functions

II. Effect on cytotoxic lymphocytes and natural killer cells

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

This study examined the effect of dietary (200 μg/d for 8 wk) supplementation with selenium (as sodium selenite) on the ability of human peripheral blood lymphocytes to respond to stimulation with alloantigen, develop into cytotoxic lymphocytes, and to destroy tumor cells, and on the activity of natural killer cells. The participants in the study were randomized for age, sex, weight, height, and nutritional habits and given selenite or placebo tablets; all participants had a selenium replete status as indicated by their plasma Se levels prior to supplementation. The data indicated that the supplementation regimen resulted in 118% increase in cytotoxic lymphocyte-mediated tumor cytotoxicity and 82.3% increase in natural killer cell activity as compared to baseline values. This apparently was related to the ability of the nutrient to enhance the expression of receptors for the growth regulatory lymphokine interleukin-2, and consequently, the rate of cell proliferation and differentiation into cytotoxic cells. The supplementation regimen did not produce significant changes in the plasma Se levels of the participants. The results indicated that the immunoenhancing effects of selenium in humans require supplementation above the replete levels produced by normal dietary intake.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
£29.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (United Kingdom)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. A. Beilstein, P. D. Whanger, and I. Wong,Selenium in Biology and Medicine, Part A, G. F. Combs, J. E. Spallholz, O. H. Levander, and J. E. Oldfield, eds., Van Nostrand Reinhold, New York, 1987, pp. 197–212.

    Google Scholar 

  2. W. C. Willet, B. V. Polk, J. S. Morris, M. J. Stampler, S. Pressil, B. Rosner, and J. Taylor,Lancet 2, 130–134 (1983).

    Article  Google Scholar 

  3. G. N. Schrauzer, D. A. White, and C. J. Schneider,Bioinorg. Chem. 7, 35–56 (977).

    Google Scholar 

  4. D. Medina and D. G. Morrison,Pathol. Immunopathol. Rev. 7, 187–198 (1988).

    CAS  Google Scholar 

  5. L. Kiremidjian-Schumacher and G. Stotzky,Environ. Res. 42, 277–303 (1987).

    Article  PubMed  CAS  Google Scholar 

  6. M. Roy, L. Kiremidjian-Schumacher, H. I. Wishe, M. W. Cohen, and G. Stotzky,Proc. Soc. Exp. Biol. Med. 193, 143–148 (1990).

    PubMed  CAS  Google Scholar 

  7. L. Kiremidjian-Schumacher, M. Roy, H. I. Wishe, M. W. Cohen, and G. Stotzky,J. Nutr. Immunol. 1, 65–67 (1992).

    CAS  Google Scholar 

  8. M. Roy, L. Kiremidjian-Schumacher, H. I. Wishe, M. W. Cohen, and G. Stotzky,Proc. Soc. Exp. Biol. Med. 200, 36–43 (1992).

    PubMed  CAS  Google Scholar 

  9. M. Roy, L. Kiremidjian-Schumacher, H. I. Wishe, M. W. Cohen, and G. Stotzky,Proc. Soc. Exp. Biol. Med. 202, 295–301 (1993).

    PubMed  CAS  Google Scholar 

  10. L. Kiremidjian-Schumacher, M. Roy, H. I. Wishe, M. W. Cohen, and G. Stotzky,Biol. Trace Elem. Res. 33, 23–35 (1992).

    Article  PubMed  CAS  Google Scholar 

  11. Committee on Dietary Allowances, Food and Nutrition Board, National Research Council. Recommended dietary allowances. 9th ed. Washington, DC., National Academy Press (1980).

    Google Scholar 

  12. J. E. Spallholz, G. F. Collins, and K. A. Schwartz,Bioinorg. Chem. 9, 453–459 (1978).

    Article  CAS  Google Scholar 

  13. S. J. Bol, H. J. Rosdorff, C. P. Ronteltap, and L. A. Hennen,J. Immunol. Meth. 90, 15–23 (1986).

    Article  CAS  Google Scholar 

  14. M. H. Julius, E. Simpson, and L. A. Herzenberg,Eur. J. Immunol. 3, 645–649 (1973).

    Article  PubMed  CAS  Google Scholar 

  15. M. G. Roncarolo, M. Bigler, J. B. Haanen, H. Yssel, R. Bacchetta, J. E. de Vries, and H. Spits,J. Immunol. 147, 781–787 (1991).

    PubMed  CAS  Google Scholar 

  16. B. G. Brenner, G. Friedman, and R. G. Margolese,Cancer 56, 1543–1548 (1985).

    Article  PubMed  CAS  Google Scholar 

  17. L. Olmsted, G. N. Schrauzer, M. F. Arce, and J. Dowd,Biol. Trace Elem. Res. 20, 59–65 (1989).

    Article  PubMed  CAS  Google Scholar 

  18. G. N. Schrauzer, and D. A. White,Bioinorg. Chem. 8, 303–318 (1978).

    Article  PubMed  CAS  Google Scholar 

  19. H. M. Meltzer, G. Norheim, E. G. Loken, and H. Holm,Br. J. Nutr. 67, 287–294 (1992).

    Article  PubMed  CAS  Google Scholar 

  20. H. M. Meltzer, G. Norheim, K. Bibow, K. Myhre, and H. Holm,Eur. J. Clin. Nutr. 44, 435–446 (1990).

    PubMed  CAS  Google Scholar 

  21. A. E. Chang and S. Shu,Cancer Invest. 10, 357–369 (1992).

    Article  PubMed  Google Scholar 

  22. H. Umehara and E. T. Bloom,Immunol. 70, 111–115 (1990).

    CAS  Google Scholar 

  23. T. A. Waldman,Annu. Rev. Biochem. 58, 875–911 (1989).

    Article  Google Scholar 

  24. K. A. Smith,Science 240, 1169–1176 (1988).

    Article  PubMed  CAS  Google Scholar 

  25. M. Roy, L. Kiremidjian-Schumacher, H. I. Wishe, M. W. Cohen, and G. Stotzky,Biol. Trace Elem. Res. this issue (1994).

  26. K. Ullman, J. B. Northrop, C. L. Verweij, and G. R. Grabtree,Annu. Rev. Immunol. 8, 421–452 (1990).

    Article  PubMed  CAS  Google Scholar 

  27. D. A. Cantrell and K. A. Smith,J. Exp. Med. 158, 1985–1911 (1983).

    Article  Google Scholar 

  28. K. J. Einspahr, R. T. Abraham, C. J. Dick, and P. J. Leibson,J. Leuk. Biol. 52, 565–571 (1992).

    CAS  Google Scholar 

  29. A. Nagler, L. L. Lanier, and J. H. Phillips,J. Exp. Med. 171, 1527–1533 (1990).

    Article  PubMed  CAS  Google Scholar 

  30. G. Trinchieri, M. Matsumoto-Koboyashi, S. G. Clark, J. Sheehra, L. London, and B. Perussia,J. Exp. Med. 160, 1147–1169 (1989).

    Article  Google Scholar 

  31. C. S. Henney, K. Kuribayashi, D. E. Kern, and S. Gillis,Nature 291, 335–338 (1981).

    Article  PubMed  CAS  Google Scholar 

  32. L. Kiremidjian-Schumacher, M. Roy, H. I. Wishe, M. W. Cohen, and G. Stotzky,Proc. Soc. Exp. Biol. Med. 193, 136–142 (1990).

    PubMed  CAS  Google Scholar 

  33. G. H. Schranzer,Biol. Trace Elem. Res. 33, 51–62 (1992).

    Article  Google Scholar 

  34. R. F. Burk,J. Nutr. 116, 1584–1586 (1986).

    PubMed  CAS  Google Scholar 

  35. M. Janghorbani, R. F. Martin, L. J. Kasper, X. F. Sun, and V. R. Young,Am. J. Clin. Nutr. 1, 670–677 (1990).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Oral Medicine and Pathology, New York University Dental Center, 10010, New York

    Lidia Kiremidjian-Schumacher & Martin W. Cohen

  2. Department of Histology and Cell Biology, New York University Dental Center, 10010, New York

    Martin Roy & Harvey I. Wishe

  3. Biology Department, New York University, New York

    Günther Stotzky

Authors
  1. Lidia Kiremidjian-Schumacher
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Martin Roy
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Harvey I. Wishe
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Martin W. Cohen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Günther Stotzky
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kiremidjian-Schumacher, L., Roy, M., Wishe, H.I. et al. Supplementation with selenium and human immune cell functions. Biol Trace Elem Res 41, 115–127 (1994). https://doi.org/10.1007/BF02917222

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02917222

Index Entries

Search

Navigation