Abstract
Since abnormalities of serum lipids and lipoproteins are highly prevalent in NIDDM they are considered as potential factors contributing to the increased CHD risk. On the other hand the link between hyperinsulinism and dyslipidemias is well-established although the causal relationship is not clear despite extensive studies. There is ample evidence that both conditions are associated with various metabolic abnormalities like hypertension, upper body obesity and NIDDM which are part of disease cluster named Syndrome X by Reaven1 or the so-called “deadly quartet”2. Growing evidence indicate that hypertriglyceridemia and low HDL cholesterol, which characterize insulin resistance, play a role in atherogenesis and contribute to CHD risk.
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Taskinen, MR. (1993). Hyperinsulinism and Dyslipidemias as Coronary Heart Disease Risk Factors in NIDDM. In: Östenson, C.G., Efendić, S., Vranic, M. (eds) New Concepts in the Pathogenesis of NIDDM. Advances in Experimental Medicine and Biology, vol 334. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2910-1_23
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DOI: https://doi.org/10.1007/978-1-4615-2910-1_23
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