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Using the SVM Method for Lung Adenocarcinoma Prognosis Based on Expression Level

Published: 11 October 2018 Publication History

Abstract

Lung cancer is the deadliest cancer in the word, leading to over a quarter of death in the United States in 2017. Gaining precise information on cancer prognosis for patients would greatly benefit their decision making for further treatment plans. While previous studies tend to use histology information and genomic signatures for cancer prognosis, this study explores the possibility of using expression level alone to predict prognosis. Using over 200 patients from publicly available datasets with overall survival length and transcriptomic information, we use support vector machines to predict prognosis. Our result proves the effectiveness of such methodology, encouraging transcriptomic data to be collected for patients routinely if possible given the decreasing cost of RNA-Seq.

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  1. Using the SVM Method for Lung Adenocarcinoma Prognosis Based on Expression Level

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    ICCBB '18: Proceedings of the 2018 2nd International Conference on Computational Biology and Bioinformatics
    October 2018
    89 pages
    ISBN:9781450365529
    DOI:10.1145/3290818
    Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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    New York, NY, United States

    Publication History

    Published: 11 October 2018

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    Author Tags

    1. Cancer prognosis
    2. Expression level
    3. Lung cancer
    4. Machine learning
    5. SVM

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