Immunoinformatic approach to a multi-pathogen genome-derived epitope-driven vaccine
Pages 616 - 620
Abstract
The first step in the development of any rationally designed or "immunome-derived" vaccine is the identification of a target organism and associated protein antigens. Once identified, candidate proteins may be evaluated for T cell epitope content. T cell epitopes are the minimal protein components that can interact with T cell receptors to stimulate the immune system. These are critical antigens for protection against infectious pathogens. In the context of this project, we are developing an epitope-based multipathogen prophylactic vaccine based on defined epitopes for F. tularensis and new epitopes for Burkholderia pseudomallei, Burkholderia mallei, and Burkholderia cepaciae.
References
[1]
Benson, D. A., Karsch-Mizrachi, I., Lipman, D. J., Ostell, J., Wheeler, D. L. 2005. Genbank. Nucleic Acids Res. 33 (Jan 2005), D34--D38.
[2]
De Groot, A. S., Bishop, E. A., Khan, B., Lally, M., Marcon, L., Franco, J., Mayer, K. H., Carpenter, C. C., Martin, W. 2004. Engineering immunogenic consensus T helper epitopes for a cross-clade HIV vaccine. Methods. 34, 4 (Dec 2004), 476--487.
[3]
De Groot, A. S., Jesdale, B. M., Szu E., Schafer J. R., Chicz R. M., Deocampo G. 1997. An interactive website providing major histocompatibility ligand predictions: application to HIV research. AIDS Res Hu Retroviruses. 13, 7 (May 1997), 529--531.
[4]
Golovliov, I., Baranov, V., Krocova, Z., Kovarova, H., Sjostedt, A. 2003. An attenuated strain of the facultative intracellular bacterium Francisella tularensis can escape the phagosome of monocytic cells. Infect Immuno. 71, 10 (Oct 2003), 5940--5950.
[5]
Junker, A. S., Willenbrock, H., von Heijne, G., Nielsen, H. Brunak, S., Krogh, A. 2003. Prediction of lipoprotein signal peptides in grame-negative bacteria. Protein Sci. 12, 8 (Aug 2003), 1652--1662.
[6]
Kall, L., Krogh, A., Sonnhammer, E. 2004. A combined transmembrane topology and signal peptide prediction method. J Mol Biol. 338, 5 (May 2004), 1027--1036.
[7]
Kyte, J. and Doolittle, R. 1982. A simple method for displaying the hydropathic character of a protein. J Mol. Biol. 157, 1 (May 1982), 105--132.
[8]
Lai, X. H., Golovliov, I., Sjostedt, A. 2001. Francisella tularensis induces cytopathogenicity and apoptosis in murine macrophages via a mechanism that requires intracellular bacterial multiplication. Infect Immun. 69, 7 (Jul 2001), 4691--4694.
[9]
Lipuma, J. J. 2005. Update on the Burkholderia cepaciae complex. Curr Opin Pulm Med. 11, 6 (Nov. 2005), 528--533.
[10]
Mahenthiralingam, E., Urban, T., Goldberg, J. 2005. The multifarious, multireplicon Burkholderia cepaciae complex. Nat Rev Microbiol. 3, 2 (Feb. 2005), 144--156.
[11]
McMurry, J. A., Gregory, S. H., Moise, L., Rivera, D., Buus, S., De Groot, A. S. 2007. Diversity of Francisella tularensis SCHU S4 antigens recognized by T lymphocytes after natural infections in humans: Identification of candidate epitopes for inclusion in a rationally designed tularemia vaccine. Vaccine. 25, 16 (Apr 2007), 3179--3191.
[12]
Moise, L., McMurry, J. A., Buus, S., Frey, S., Martin, W., De Groot, A. S. 2009. In silico-accelerated identification of conserved and immunogenic variola/vaccinia T cell epitopes. Vaccine. 27, 46 (October 2009), 6471--6479.
[13]
Moise, L., Buller, R. M., Schriewer, J., Lee, J., Frey, S., Martin, W., De Groot, A. S. 2010. VennVax, a DNA-prime, peptide-boost, multi-T-cell epitope vaccine, induces protective immunity against vaccinia infection by T cell response alone. {In Press}.
[14]
Southwood, S., Sidney, J., Kondo, A., del Guercio, M. F., Appella, E., Hoffman, S., Kubo, R. T., Chestnut, R. W., Grey, H. M., Sette, A. 1998. Several common HLA-DR types share largely overlapping peptide binding repertoires. J Immunol. 160, 7 (Apr 1998), 3363--3373.
Index Terms
- Immunoinformatic approach to a multi-pathogen genome-derived epitope-driven vaccine
Recommendations
Immunoinformatic-driven H. pylori vaccine design
BCB '10: Proceedings of the First ACM International Conference on Bioinformatics and Computational BiologyOne useful application of pattern matching algorithms is identification of major histocompatability complex (MHC) ligands and T-cell epitopes. Peptides that bind to MHC molecules and interact with T cell receptors to stimulate the immune system are ...
Immunoinformatic discovery of potential cross-reactive T cell epitopes in the measles genome
BCB '11: Proceedings of the 2nd ACM Conference on Bioinformatics, Computational Biology and BiomedicineT cells are key mediators of inflammatory processes that can be activated by pathogens and vaccines. Some vaccine antigens may encode T cell epitopes that can cross-react with either human or human microbiome epitopes, causing deviation of the T cell ...
Exploring SARS-COV-2 structural proteins to design a multi-epitope vaccine using immunoinformatics approach: An in silico study
AbstractIn December 2019, a new virus called SARS-CoV-2 was reported in China and quickly spread to other parts of the world. The development of SARS-COV-2 vaccines has recently received much attention from numerous researchers. The present study aims to ...
Highlights- To design a multi-epitope vaccine against SARS-COV-2, we used a set of bioinformatics approaches.
- The vaccine was designed using several epitopes, adjuvant, and appropriate linkers.
- The prediction of secondary and 3D models of the ...
Comments
Please enable JavaScript to view thecomments powered by Disqus.Information & Contributors
Information
Published In
August 2010
705 pages
ISBN:9781450304382
DOI:10.1145/1854776
- General Chairs:
- Aidong Zhang,
- Mark Borodovsky,
- Program Chairs:
- Gultekin Ozsoyoglu,
- Armin Mikler
Copyright © 2010 ACM.
Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]
Sponsors
Publisher
Association for Computing Machinery
New York, NY, United States
Publication History
Published: 02 August 2010
Check for updates
Author Tags
Qualifiers
- Research-article
Conference
BCB'10
Sponsor:
BCB'10: ACM International Conference on Bioinformatics and Computational Biology
August 2 - 4, 2010
New York, Niagara Falls
Acceptance Rates
Overall Acceptance Rate 254 of 885 submissions, 29%
Contributors
Other Metrics
Bibliometrics & Citations
Bibliometrics
Article Metrics
- 0Total Citations
- 95Total Downloads
- Downloads (Last 12 months)3
- Downloads (Last 6 weeks)2
Reflects downloads up to 24 Jan 2025
Other Metrics
Citations
View Options
Login options
Check if you have access through your login credentials or your institution to get full access on this article.
Sign in