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Merging partially labelled trees: hardness and a declarative programming solution

Published: 01 March 2014 Publication History

Abstract

Intraspecific studies often make use of haplotype networks instead of gene genealogies to represent the evolution of a set of genes. Cassens et al. [3] proposed one such network reconstruction method, based on the global maximum parsimony principle, which was later recast by the first author of the present work as the problem of finding a minimum common supergraph of a set of t partially labelled trees. Although algorithms have been proposed for solving that problem on two graphs, the complexity of the general problem on trees remains unknown. In this paper, we show that the corresponding decision problem is NP-complete for t = 3. We then propose a declarative programming approach to solving the problem to optimality in practice, as well as a heuristic approach, both based on the IDP system, and assess the performance of both methods on randomly generated data.

References

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I. Cassens, P. Mardulyn, and M.C. Milinkovitch, "Evaluating Intraspecific "Network" Construction Methods Using Simulated Sequence Data: Do Existing Algorithms Outperform the Global Maximum Parsimony Approach?" Systematic Biology, vol. 54, no. 3, pp. 363-372, June 2005.
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Information & Contributors

Information

Published In

cover image IEEE/ACM Transactions on Computational Biology and Bioinformatics
IEEE/ACM Transactions on Computational Biology and Bioinformatics  Volume 11, Issue 2
March/April 2014
160 pages

Publisher

IEEE Computer Society Press

Washington, DC, United States

Publication History

Published: 01 March 2014
Accepted: 10 February 2014
Revised: 02 December 2013
Received: 21 June 2013
Published in TCBB Volume 11, Issue 2

Author Tags

  1. IDP
  2. NP-hardness
  3. SAT solver
  4. phylogenetic networks
  5. supergraphs

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