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Supervised parametric and non-parametric classification of chromosome images

Published: 01 August 2005 Publication History

Abstract

This paper describes a fully automatic chromosome classification algorithm for Multiplex Fluorescence In Situ Hybridization (M-FISH) images using supervised parametric and non-parametric techniques. M-FISH is a recently developed chromosome imaging method in which each chromosome is labelled with 5 fluors (dyes) and a DNA stain. The classification problem is modelled as a 25-class 6-feature pixel-by-pixel classification task. The 25 classes are the 24 types of human chromosomes and the background, while the six features correspond to the brightness of the dyes at each pixel. Maximum likelihood estimation, nearest neighbor and k-nearest neighbor methods are implemented for the classification. The highest classification accuracy is achieved with the k-nearest neighbor method and k=7 is an optimal value for this classification task.

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Cited By

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  • (2022)Chromenet: a CNN architecture with comparison of optimizers for classification of human chromosome imagesMultidimensional Systems and Signal Processing10.1007/s11045-022-00819-x33:3(747-768)Online publication date: 1-Sep-2022
  • (2016)Investigating machine learning techniques for the detection of autismInternational Journal of Data Mining and Bioinformatics10.1504/IJDMB.2016.08004016:2(141-169)Online publication date: 1-Jan-2016
  • (2013)Automated classification of touching or overlapping M-FISH chromosomes by region fusion and homolog pairingPattern Analysis & Applications10.1007/s10044-012-0301-y16:1(31-39)Online publication date: 1-Feb-2013
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Information & Contributors

Information

Published In

cover image Pattern Recognition
Pattern Recognition  Volume 38, Issue 8
August, 2005
181 pages

Publisher

Elsevier Science Inc.

United States

Publication History

Published: 01 August 2005

Author Tags

  1. Karyotyping
  2. M-FISH
  3. Maximum likelihood estimation
  4. Nearest neighbor
  5. k-nearest neighbor

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Cited By

View all
  • (2022)Chromenet: a CNN architecture with comparison of optimizers for classification of human chromosome imagesMultidimensional Systems and Signal Processing10.1007/s11045-022-00819-x33:3(747-768)Online publication date: 1-Sep-2022
  • (2016)Investigating machine learning techniques for the detection of autismInternational Journal of Data Mining and Bioinformatics10.1504/IJDMB.2016.08004016:2(141-169)Online publication date: 1-Jan-2016
  • (2013)Automated classification of touching or overlapping M-FISH chromosomes by region fusion and homolog pairingPattern Analysis & Applications10.1007/s10044-012-0301-y16:1(31-39)Online publication date: 1-Feb-2013
  • (2009)Enhancement of multichannel chromosome classification using a region-based classifier and vector median filteringIEEE Transactions on Information Technology in Biomedicine10.1109/TITB.2008.200871613:4(561-570)Online publication date: 1-Jul-2009
  • (2007)Biological shape characterization for automatic image recognition and diagnosis of protozoan parasites of the genus EimeriaPattern Recognition10.1016/j.patcog.2006.12.00640:7(1899-1910)Online publication date: 1-Jul-2007

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