Article

How Bursts Shape the STDP Curve in the Presence/Absence of GABAergic Inhibition

Authors:

Vassilis Cutsuridis,

Stuart Cobb,

Bruce P. GrahamAuthors Info & Claims

ICANN '09: Proceedings of the 19th International Conference on Artificial Neural Networks: Part I

Pages 229 - 238

https://doi.org/10.1007/978-3-642-04274-4_24

Published: 15 September 2009 Publication History

Abstract

It has been known for some time that the synapses of the CA1 pyramidal cells are surprisingly unreliable at signalling the arrival of single spikes to the postsynaptic neuron [2]. On the other hand, bursts of spikes are reliably signalled, because transmitter release is facilitated. In the hippocampus, a single burst can produce long-term synaptic modifications. Bursts of spikes in addition to increasing reliability of synaptic transmission [3], they have been shown to provide effective mechanisms for selective communication between neurons in a network [4]. We investigate via computer simulations how the profile of spike-timing-dependent plasticity (STDP) in the CA1 pyramidal cell synapses is affected when an excitatory burst of spikes applied to dendrites is paired with an excitatory single spike applied to the soma in the absence and presence of a 100Hz GABAergic inhibitory spike train applied to the dendrites. We report that the shape of the STDP curve strongly depends on the burst interspike interval in the presence/absence of GABA_<em>A</em> when a presynaptic burst and a postsynaptic spike are paired together.

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Cited By

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Cutsuridis V(2010)Action potential bursts modulate the NMDA-R mediated spike timing dependent plasticity in a biophysical modelProceedings of the 20th international conference on Artificial neural networks: Part I10.5555/1886351.1886369(107-116)Online publication date: 15-Sep-2010
https://dl.acm.org/doi/10.5555/1886351.1886369

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Synaptic strength can be modified by the relative timing of pre- and postsynaptic activity, a phenomenon termed spike timing-dependent plasticity (STDP). Studies of neurons in the hippocampus and in other regions have found that when presynaptic ...

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Published In

ICANN '09: Proceedings of the 19th International Conference on Artificial Neural Networks: Part I

September 2009

1024 pages

ISBN:9783642042737

Editors:
Cesare Alippi
Dipartimento di Elettronica, Politecnico di Milano, Milano, Italy 20133
,
Marios Polycarpou
Department of Electrical and Computer Engineering, University of Cyprus, Nicosia, Cyprus 1678
,
Christos Panayiotou
Department of Electrical and Computer Engineering, University of Cyprus, Nicosia, Cyprus 1678
,
Georgios Ellinas
Department of Electrical and Computer Engineering, University of Cyprus, Nicosia, Cyprus 1678

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Springer-Verlag

Berlin, Heidelberg

Publication History

Published: 15 September 2009

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Cutsuridis V(2010)Action potential bursts modulate the NMDA-R mediated spike timing dependent plasticity in a biophysical modelProceedings of the 20th international conference on Artificial neural networks: Part I10.5555/1886351.1886369(107-116)Online publication date: 15-Sep-2010
https://dl.acm.org/doi/10.5555/1886351.1886369

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Recommendations

A CA2 + Dynamics Model of the STDP Symmetry-to-Asymmetry Transition in the CA1 Pyramidal Cell of the Hippocampus

GABA inhibition modulates NMDA-R mediated spike timing dependent plasticity (STDP) in a biophysical model

Interplay of the magnitude and time-course of postsynaptic Ca2+ concentration in producing spike timing-dependent plasticity

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Interplay of the magnitude and time-course of postsynaptic Ca²⁺ concentration in producing spike timing-dependent plasticity