[go: up one dir, main page]
More Web Proxy on the site http://driver.im/
Skip to main content
We gratefully acknowledge support from the Simons Foundation, member institutions, and all contributors. Donate
arXiv logo
Cornell University Logo

Quantitative Biology > Tissues and Organs

arXiv:2403.05909 (q-bio)
[Submitted on 9 Mar 2024]

Title:An in-silico approach to meniscus tissue regeneration: Modeling, numerical simulation, and experimental analysis

Authors:Elise Grosjean, Alex Keilmann, Henry Jäger, Shimi Mohanan, Claudia Redenbach, Bernd Simeon, Christina Surulescu, Luisa de Roy, Andreas Seitz, Graciosa Teixeira, Martin Dauner, Carsten Linti, Günter Schmidt
View PDF HTML (experimental)
Abstract:We develop a model the dynamics of human mesenchymal stem cells (hMSCs) and chondrocytes evolving in a nonwoven polyethylene terephtalate (PET) scaffold impregnated with hyaluron and supplied with a differentiation medium. The scaffold and the cells are assumed to be contained in a bioreactor with fluid perfusion. The differentiation of hMSCs into chondrocytes favors the production of extracellular matrix (ECM) and is influenced by fluid stress. The model takes deformations of ECM and PET scaffold into account. The scaffold structure is explicitly included by statistical assessment of the fibre distribution from CT images. The effective macroscopic equations are obtained by appropriate upscaling from dynamics on lower (microscopic and mesoscopic) scales and feature in the motility terms an explicit cell diffusion tensor encoding the assessed anisotropic scaffold structure. Numerical simulations show its influence on the overall cell and tissue dynamics.
Subjects: Tissues and Organs (q-bio.TO); Analysis of PDEs (math.AP); Numerical Analysis (math.NA); Cell Behavior (q-bio.CB); Quantitative Methods (q-bio.QM)
Cite as: arXiv:2403.05909 [q-bio.TO]
  (or arXiv:2403.05909v1 [q-bio.TO] for this version)
  https://doi.org/10.48550/arXiv.2403.05909

Submission history

From: Christina Surulescu [view email]
[v1] Sat, 9 Mar 2024 13:24:55 UTC (10,157 KB)
Full-text links:

Access Paper:

view license
Current browse context:
q-bio.TO
< prev   |   next >
new | recent | 2024-03
Change to browse by:
cs
cs.NA
math
math.AP
math.NA
q-bio
q-bio.CB
q-bio.QM

References & Citations

export BibTeX citation

Bookmark

BibSonomy logo Reddit logo

Bibliographic and Citation Tools

Bibliographic Explorer (What is the Explorer?)
Connected Papers (What is Connected Papers?)
Litmaps (What is Litmaps?)
scite Smart Citations (What are Smart Citations?)

Code, Data and Media Associated with this Article

alphaXiv (What is alphaXiv?)
CatalyzeX Code Finder for Papers (What is CatalyzeX?)
DagsHub (What is DagsHub?)
Gotit.pub (What is GotitPub?)
Hugging Face (What is Huggingface?)
Papers with Code (What is Papers with Code?)
ScienceCast (What is ScienceCast?)

Demos

Replicate (What is Replicate?)
Hugging Face Spaces (What is Spaces?)
TXYZ.AI (What is TXYZ.AI?)

Recommenders and Search Tools

Influence Flower (What are Influence Flowers?)
CORE Recommender (What is CORE?)

arXivLabs: experimental projects with community collaborators

arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website.

Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them.

Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.

Which authors of this paper are endorsers? | Disable MathJax (What is MathJax?)