Naegleria fowleri: Portrait of a Cerebral Killer
<p>Cranial CT scan images of the 10-month-old patient demonstrating acute hydrocephalus. The scans show significant enlargement of the lateral ventricles due to increased intracranial pressure caused by severe cerebral edema. These findings are consistent with advanced primary amebic meningoencephalitis (PAM), highlighting the rapid progression of the disease and its impact on the central nervous system.</p> "> Figure 2
<p>The “brain-eating” ameba in CSF were detected by direct microscopic examination under the wet preparation that showed the flagellated form (<b>A</b>) and the trophozoites form (<b>B</b>). Original magnification ×40.</p> ">
Abstract
:1. Background
2. Case Presentation
3. Discussion
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameters | Admission Day 1 Disease Progress Day 3 | Admission Day 3 Disease Progress Day 5 |
---|---|---|
WBC (103/μL) | 13.4 | 5.69 |
NEU (103/μL) | 10.1 | 4.72 |
LYM (103/μL) | 2.0 | 0.79 |
Hb (g/dL) | 9.9 | 10.8 |
PLT (103/μL) | 264 | 151 |
CRP (mg/L) | 151 | 179.2 |
AST (U/L) | 38.2 | 91.5 |
ALT (U/L) | 11.9 | 32.3 |
Creatinine (μmol/L) | 32 | 25.8 |
CSF cells (cells/mm3) | 4032 (88% polymorphonuclear leukocytes) | 962 (85% polymorphonuclear leukocytes) |
CSF/serum glucose (%) | 26 | 66 |
CSF lactate (mmol/L) | 11.8 | 10.3 |
CSF protein (g/L) | 32.4 | 34.3 |
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Phung, N.T.N.; Pham, H.T.; Tran, T.T.; Dinh, V.H.; Tran, N.M.; Tran, N.A.N.; Ngo, M.Q.N.; Nguyen, H.T.T.; Tran, D.K.; Le, T.K.T.; et al. Naegleria fowleri: Portrait of a Cerebral Killer. Diagnostics 2025, 15, 89. https://doi.org/10.3390/diagnostics15010089
Phung NTN, Pham HT, Tran TT, Dinh VH, Tran NM, Tran NAN, Ngo MQN, Nguyen HTT, Tran DK, Le TKT, et al. Naegleria fowleri: Portrait of a Cerebral Killer. Diagnostics. 2025; 15(1):89. https://doi.org/10.3390/diagnostics15010089
Chicago/Turabian StylePhung, Nguyen The Nguyen, Huong Thien Pham, Thuc Thanh Tran, Vu Hoang Dinh, Nhut Minh Tran, Nuong Ai Nguyen Tran, Minh Quang Ngoc Ngo, Huong Thanh Thi Nguyen, Duy Khanh Tran, Thao Kieu Thi Le, and et al. 2025. "Naegleria fowleri: Portrait of a Cerebral Killer" Diagnostics 15, no. 1: 89. https://doi.org/10.3390/diagnostics15010089
APA StylePhung, N. T. N., Pham, H. T., Tran, T. T., Dinh, V. H., Tran, N. M., Tran, N. A. N., Ngo, M. Q. N., Nguyen, H. T. T., Tran, D. K., Le, T. K. T., Quek, C., Pham, V. H., & Pham, S. T. (2025). Naegleria fowleri: Portrait of a Cerebral Killer. Diagnostics, 15(1), 89. https://doi.org/10.3390/diagnostics15010089