Impact of ROS Generated by Chemical, Physical, and Plasma Techniques on Cancer Attenuation
<p>Schematic of primary reactive oxygen species (ROS) production mechanism.</p> "> Figure 2
<p>Some major intracellular (mitochondria, peroxisome, endoplasmic reticulum (ER) stress, nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase, metabolizing enzymes) and extracellular (Radiations, Xenobiotics) sources of reactive oxygen species (ROS) generation [<a href="#B81-cancers-11-01030" class="html-bibr">81</a>].</p> "> Figure 3
<p>Role of reactive oxygen species (ROS) in cancer inhibition by four different mechanisms and the different pathways involved in those mechanisms.</p> "> Figure 4
<p>Molecular mechanism of soft-jet plasma-induced cancer cell apoptosis via the mitochondrial intrinsic pathway and extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) activation [<a href="#B250-cancers-11-01030" class="html-bibr">250</a>].</p> ">
Abstract
:1. Introduction
2. Types of Reactive Oxygen Species
2.1. Singlet Oxygen
2.2. Superoxide Anion •O2−
2.3. Hydroxyl Radicals
2.4. Hydrogen Peroxide
3. Generation of ROS
3.1. Intracellular Production of ROS
3.2. Roles of Different Enzyme and Protein Expression Levels during the Intracellular Production of ROS
3.3. Generation of ROS by Chemicals
3.4. Generation of ROS by Radiation
3.5. ROS Production by Plasma
3.6. ROS Production by Anticancer Drugs during Cancer Therapy
4. ROS Roles in Cellular Mechanisms for the Inhibition of Cancers
4.1. Adaptation
4.2. Apoptosis
4.3. Autophagy
4.4. Increased Action and Sensitivity of Anticancer Agents by ROS
5. Role of Plasma in the Inhibition of Cancer and its Mechanism
6. Future Perspective
Author Contributions
Funding
Conflicts of Interest
References
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Published Year | Anticancer Agent | Types of Cancer | Mechanism |
---|---|---|---|
1999 | Doxorubicin | Lung cancer [152] | BRAF inhibition by ROS [152,153] |
2018 | Actinomycin D or Decitabine | Skin cancer [154] | Production of reactive species [155] |
2018 | Vinorelbine | Lung cancer [156] | ROS induced mechanism [137] |
2014 | Vinblastine | Lung cancer and breast cancer [157] | Apoptosis induced by ROS [136] |
2009 | Camptothecin | Cervical and uterus cancer [158] | Cell death induced by ROS |
2006 2014 | Paclitaxel | Lung cancer [159] Breast cancer [160] | ROS-dependent activation of apoptotic cell death [161] |
2012 | Taxol | Blood cancer [162] | Apoptosis by generation of ROS [162] |
2017 | Epirubicin | Breast cancer [163] | Programmed death of cell by ROS [163] |
2012 | Resveratrol | Colon cancer [164] | ROS production [164] |
2015 | Colchicine | Colon cancer [165] | Increase ROS production in a dose dependent manner [165] |
Treatment Methods | Mechanism | Reference |
---|---|---|
Sonodynamic therapy (SDT) | Alter cancer microenvironment by enhancing ROS level | [228] |
Tyrosin kinase inhibitor (TKI) | ROS inducing effect | [227] |
Monoclonal antibody | ROS mediated apotosis | [227] |
Anti-tumor immune action | By targeting tumor-associated macrophage by ROS | [229] |
Nanomedicine combination with anticancer drugs | ROS-inducing effect | [230] |
Published Year | Plasma Equipment | Types of Cancer | Mechanism | Reference |
---|---|---|---|---|
2017 | Plasma jet | Pancreatic cancer | Hydrogen peroxide | [259] |
2017 | DBD plasma device | Cervical cancer | Hydrogen peroxide | [260] |
2014 | Plasma jet | Head and neck cancer | DNA damage by ROS | [261] |
2016 | Plasma generated in DI water | Gastric cancer | ROS-induced apoptosis | [262] |
2017 | Air plasma by high voltage electrode | Triple negative breast cancer | Hydrogen peroxide-induced apoptosis | [256] |
2016 | Microplasma jet produced liquid plasma | Triple negative breast cancer | ROS and RNS-induced apoptosis | [263] |
2017 | DBD plasma device | Lung cancer | Apoptosis induced by ROS and RNS | [264] |
2015 | Water vapor with plasma jet | Breast cancer | Hydrogen peroxide-induced apoptosis | [265] |
2017 | DBD plasma | Colon cancer | Apoptosis and DNA damage by ROS | [266] |
2013 | Jet plasma | Brain cancer | Plasma caused cell death | [267] |
2016 | DBD plasma | Brain cancer | ROS-induced apoptosis | [268] |
2012 | DBD plasma | Brain and colorectal cancer | Apoptosis and DNA damage by ROS | [22] |
2014 | DBD plasma | Thyroid cancer, Oral cancer | ROS-induced DNA damage and apotosis | [238] |
2013 | Plasma-treated media | Blood cancer | ROS-induced apoptosis | [269] |
2014 | DBD plasma | Blood cancer | ROS-initiated apoptosis-related gene expression | [270] |
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Mitra, S.; Nguyen, L.N.; Akter, M.; Park, G.; Choi, E.H.; Kaushik, N.K. Impact of ROS Generated by Chemical, Physical, and Plasma Techniques on Cancer Attenuation. Cancers 2019, 11, 1030. https://doi.org/10.3390/cancers11071030
Mitra S, Nguyen LN, Akter M, Park G, Choi EH, Kaushik NK. Impact of ROS Generated by Chemical, Physical, and Plasma Techniques on Cancer Attenuation. Cancers. 2019; 11(7):1030. https://doi.org/10.3390/cancers11071030
Chicago/Turabian StyleMitra, Sarmistha, Linh Nhat Nguyen, Mahmuda Akter, Gyungsoon Park, Eun Ha Choi, and Nagendra Kumar Kaushik. 2019. "Impact of ROS Generated by Chemical, Physical, and Plasma Techniques on Cancer Attenuation" Cancers 11, no. 7: 1030. https://doi.org/10.3390/cancers11071030
APA StyleMitra, S., Nguyen, L. N., Akter, M., Park, G., Choi, E. H., & Kaushik, N. K. (2019). Impact of ROS Generated by Chemical, Physical, and Plasma Techniques on Cancer Attenuation. Cancers, 11(7), 1030. https://doi.org/10.3390/cancers11071030