Narrative Review of Single-Port Surgery in Genitourinary Cancers
1. Introduction
2. Radical Prostatectomy
2.1. Transperitoneal SP-RARP
2.2. Extraperitoneal
2.3. Transvesical
3. Radical Cystectomy
4. Nephrectomy
4.1. Partial and Radical Nephrectomy
4.2. Retroperitoneal and Low Anterior Access (LAA)
5. Nephroureterectomy
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
- Siegel, R.L.; Miller, K.D.; Jemal, A. Cancer statistics, 2019. CA Cancer J. Clin. 2019, 69, 7–34. [Google Scholar] [CrossRef] [PubMed]
- Dy, G.W.; Gore, J.L.; Forouzanfar, M.H.; Naghavi, M.; Fitzmaurice, C. Global Burden of Urologic Cancers, 1990–2013. Eur. Urol. 2017, 71, 437–446. [Google Scholar] [CrossRef] [PubMed]
- Fahmy, O.; Asri, K.; Schwentner, C.; Stenzl, A.; Gakis, G. Current status of robotic assisted radical cystectomy with intracorporeal ileal neobladder for bladder cancer. J. Surg. Oncol. 2015, 112, 427–429. [Google Scholar] [CrossRef] [PubMed]
- Mazzone, E.; Mistretta, F.A.; Knipper, S.; Tian, Z.; Larcher, A.; Widmer, H.; Zorn, K.; Capitanio, U.; Graefen, M.; Montorsi, F.; et al. Contemporary National Assessment of Robot-Assisted Surgery Rates and Total Hospital Charges for Major Surgical Uro-Oncological Procedures in the United States. J. Endourol. 2019, 33, 438–447. [Google Scholar] [CrossRef]
- Bochner, B.H.; Kamat, A.M.; Bivalacqua, T.J. Open vs Robotic Cystectomy: Case Closed? J. Urol. 2024, 211, 473–475. [Google Scholar] [CrossRef]
- Di Benedetto, F.; Magistri, P.; Di Sandro, S. Robotic vs Open Liver Resection for Hepatocellular Carcinoma-Reply. JAMA Surg. 2023, 158, 986. [Google Scholar] [CrossRef]
- Ficarra, V.; Novara, G.; Rosen, R.C.; Artibani, W.; Carroll, P.R.; Costello, A.; Menon, M.; Montorsi, F.; Patel, V.R.; Stolzenburg, J.U.; et al. Systematic review and meta-analysis of studies reporting urinary continence recovery after robot-assisted radical prostatectomy. Eur. Urol. 2012, 62, 405–417. [Google Scholar] [CrossRef]
- Fantus, R.J.; Cohen, A.; Riedinger, C.B.; Kuchta, K.; Wang, C.H.; Yao, K.; Park, S. Facility-level analysis of robot utilization across disciplines in the National Cancer Database. J. Robot. Surg. 2019, 13, 293–299. [Google Scholar] [CrossRef]
- Kaouk, J.H.; Haber, G.P.; Autorino, R.; Crouzet, S.; Ouzzane, A.; Flamand, V.; Villers, A. A novel robotic system for single-port urologic surgery: First clinical investigation. Eur. Urol. 2014, 66, 1033–1043. [Google Scholar] [CrossRef]
- Abaza, R.; Martinez, O.; Murphy, C.; Urkmez, A.; Davis, J. Adoption of Single-Port Robotic Prostatectomy: Two Alternative Strategies. J. Endourol. 2020, 34, 1230–1234. [Google Scholar] [CrossRef]
- Covas Moschovas, M.; Kind, S.; Bhat, S.; Noel, J.; Sandri, M.; Rogers, T.; Moser, D.; Brady, I.; Patel, V. Implementing the da Vinci SP Without Increasing Positive Surgical Margins: Experience and Pathologic Outcomes of a Prostate Cancer Referral Center. J. Endourol. 2022, 36, 493–498. [Google Scholar] [CrossRef] [PubMed]
- Noh, T.I.; Kang, Y.J.; Shim, J.S.; Kang, S.H.; Cheon, J.; Lee, J.G.; Kang, S.G. Single-Port vs Multiport Robot-Assisted Radical Prostatectomy: A Propensity Score Matching Comparative Study. J. Endourol. 2022, 36, 661–667. [Google Scholar] [CrossRef]
- Abou Zeinab, M.; Beksac, A.T.; Ferguson, E. Single-port Extraperitoneal and Transperitoneal Radical Prostatectomy: A Multi-Institutional Propensity-Score Matched Study. Urology 2023, 171, 140–145. [Google Scholar] [CrossRef]
- Akand, M.; Erdogru, T.; Avci, E.; Ates, M. Transperitoneal versus extraperitoneal robot-assisted laparoscopic radical prostatectomy: A prospective single surgeon randomized comparative study. Int. J. Urol. 2015, 22, 916–921. [Google Scholar] [CrossRef]
- Agrawal, V.; Feng, C.; Joseph, J. Outcomes of Extraperitoneal Robot-Assisted Radical Prostatectomy in the Morbidly Obese: A Propensity Score-Matched Study. J. Endourol. 2015, 29, 677–682. [Google Scholar] [CrossRef] [PubMed]
- Zhou, X.; Fu, B.; Zhang, C.; Liu, W.; Guo, J.; Chen, L.; Lei, E.; Zhang, X.; Wang, G. Transvesical robot-assisted radical prostatectomy: Initial experience and surgical outcomes. BJU Int. 2020, 126, 300–308. [Google Scholar] [CrossRef] [PubMed]
- Kaouk, J.; Beksac, A.T.; Abou Zeinab, M.; Duncan, A.; Schwen, Z.R.; Eltemamy, M. Single Port Transvesical Robotic Radical Prostatectomy: Initial Clinical Experience and Description of Technique. Urology 2021, 155, 130–137. [Google Scholar] [CrossRef]
- Chang, S.S.; Bochner, B.H.; Chou, R.; Dreicer, R.; Kamat, A.M.; Lerner, S.P.; Lotan, Y.; Meeks, J.J.; Michalski, J.M.; Morgan, T.M.; et al. Treatment of Non-Metastatic Muscle-Invasive Bladder Cancer: AUA/ASCO/ASTRO/SUO Guideline. J. Urol. 2017, 198, 552–559. [Google Scholar] [CrossRef]
- Witjes, J.A.; Bruins, H.M.; Cathomas, R.; Comperat, E.M.; Cowan, N.C.; Gakis, G.; Hernandez, V.; Linares Espinos, E.; Lorch, A.; Neuzillet, Y.; et al. European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2020 Guidelines. Eur. Urol. 2021, 79, 82–104. [Google Scholar] [CrossRef]
- Menon, M.; Hemal, A.K.; Tewari, A.; Shrivastava, A.; Shoma, A.M.; El-Tabey, N.A.; Shaaban, A.; Abol-Enein, H.; Ghoneim, M.A. Nerve-sparing robot-assisted radical cystoprostatectomy and urinary diversion. BJU Int. 2003, 92, 232–236. [Google Scholar] [CrossRef]
- Parekh, D.J.; Reis, I.M.; Castle, E.P.; Gonzalgo, M.L.; Woods, M.E.; Svatek, R.S.; Weizer, A.Z.; Konety, B.R.; Tollefson, M.; Krupski, T.L.; et al. Robot-assisted radical cystectomy versus open radical cystectomy in patients with bladder cancer (RAZOR): An open-label, randomised, phase 3, non-inferiority trial. Lancet 2018, 391, 2525–2536. [Google Scholar] [CrossRef]
- Bochner, B.H.; Dalbagni, G.; Marzouk, K.H.; Sjoberg, D.D.; Lee, J.; Donat, S.M.; Coleman, J.A.; Vickers, A.; Herr, H.W.; Laudone, V.P. Randomized Trial Comparing Open Radical Cystectomy and Robot-assisted Laparoscopic Radical Cystectomy: Oncologic Outcomes. Eur. Urol. 2018, 74, 465–471. [Google Scholar] [CrossRef] [PubMed]
- Sathianathen, N.J.; Kalapara, A.; Frydenberg, M.; Lawrentschuk, N.; Weight, C.J.; Parekh, D.; Konety, B.R. Robotic Assisted Radical Cystectomy vs Open Radical Cystectomy: Systematic Review and Meta-Analysis. J. Urol. 2019, 201, 715–720. [Google Scholar] [CrossRef]
- Mehrazin, R.; Kim, E.H.; Lavallee, E.; Ahmad, M. Single-Port Robot-Assisted Radical Cystectomy. In Robotic Urologic Surgery; Wiklund, P., Mottrie, A., Gundeti, M.S., Patel, V., Eds.; Springer International Publishing: Cham, Switzerland, 2022; pp. 709–714. [Google Scholar] [CrossRef]
- Kaouk, J.; Garisto, J.; Eltemamy, M.; Bertolo, R. Step-by-step technique for single-port robot-assisted radical cystectomy and pelvic lymph nodes dissection using the da Vinci® SP™ surgical system. BJU Int. 2019, 124, 707–712. [Google Scholar] [CrossRef] [PubMed]
- Fang, A.M.; Hayek, O.; Kaylor, J.M.; Peyton, C.C.; Ferguson, J.E., 3rd; Nix, J.W.; Rais-Bahrami, S. Postoperative Outcomes and Analgesic Requirements of Single-Port vs Multiport Robotic-Assisted Radical Cystectomy. J. Endourol. 2024, 38, 438–443. [Google Scholar] [CrossRef] [PubMed]
- Zhang, M.; Thomas, D.; Salama, G.; Ahmed, M. Single port robotic radical cystectomy with intracorporeal urinary diversion: A case series and review. Transl. Androl. Urol. 2020, 9, 925–930. [Google Scholar] [CrossRef] [PubMed]
- Arora, A.; Pugliesi, F.; Zugail, A.S.; Moschini, M.; Pazeto, C.; Macek, P.; Stabile, A.; Lanz, C.; Mombet, A.; Bennamoun, M.; et al. Comparing Perioperative Complications Between Laparoscopic and Robotic Radical Cystectomy for Bladder Cancer. J Endourol. 2020, 34, 1033–1040. [Google Scholar] [CrossRef]
- Gross, J.T.; Vetter, J.M.; Sands, K.G.; Palka, J.K.; Bhayani, S.B.; Figenshau, R.S.; Kim, E.H. Initial Experience with Single-Port Robot-Assisted Radical Cystectomy: Comparison of Perioperative Outcomes Between Single-Port and Conventional Multiport Approaches. J. Endourol. 2021, 35, 1177–1183. [Google Scholar] [CrossRef]
- Ali, D.; Sawhney, R.; Billah, M.; Harrison, R.; Stifelman, M.; Lovallo, G.; Gopal, N.; Zaifman, J.; Ahsanuddin, S.; Lama-Tamang, T.; et al. Single-Port Robotic Radical Cystectomy with Intracorporeal Bowel Diversion: Initial Experience and Review of Surgical Outcomes. J. Endourol. 2022, 36, 216–223. [Google Scholar] [CrossRef]
- Crozier, J.; Papa, N.; Perera, M.; Stewart, M.; Goad, J.; Sengupta, S.; Bolton, D.; Lawrentschuk, N. Lymph node yield in node-negative patients predicts cancer specific survival following radical cystectomy for transitional cell carcinoma. Investig. Clin. Urol. 2017, 58, 416–422. [Google Scholar] [CrossRef]
- Morgan, T.M.; Barocas, D.A.; Penson, D.F.; Chang, S.S.; Ni, S.; Clark, P.E.; Smith, J.A., Jr.; Cookson, M.S. Lymph node yield at radical cystectomy predicts mortality in node-negative and not node-positive patients. Urology 2012, 80, 632–640. [Google Scholar] [CrossRef] [PubMed]
- Rich, J.M.; Okhawere, K.E.; Nguyen, C.; Ucpinar, B.; Zuluaga, L.; Razdan, S.; Saini, I.; Tuna Beksac, A.; Nguyen, J.; Calvo, R.S.; et al. Transperitoneal Versus Retroperitoneal Single-port Robotic-assisted Partial Nephrectomy: An Analysis from the Single Port Advanced Research Consortium. Eur. Urol. Focus. 2023, 9, 1059–1064. [Google Scholar] [CrossRef] [PubMed]
- Razdan, S.; Zuluaga, L.; Ucpinar, B.; Badani, K.K. Developing an Algorithm on Multiport and Single Port Use for Robotic Prostate and Kidney Surgery. AUA News 2024, 29, 23. [Google Scholar]
- Okhawere, K.E.; Beksac, A.T.; Wilson, M.P.; Korn, T.G.; Meilika, K.N.; Harrison, R.; Morgantini, L.; Ahmed, M.; Mehrazin, R.; Abaza, R.; et al. A Propensity-Matched Comparison of the Perioperative Outcomes Between Single-Port and Multi-Port Robotic Assisted Partial Nephrectomy: A Report from the Single Port Advanced Research Consortium (SPARC). J. Endourol. 2022, 36, 1526–1531. [Google Scholar] [CrossRef] [PubMed]
- Nguyen, T.T.; Ngo, X.T.; Duong, N.X.; Dobbs, R.W.; Vuong, H.G.; Nguyen, D.D.; Basilius, J.; Onder, N.K.; Mendiola, D.F.; Hoang, T.D.; et al. Single-Port vs Multiport Robot-Assisted Partial Nephrectomy: A Meta-Analysis. J. Endourol. 2024, 38, 253–261. [Google Scholar] [CrossRef]
- Fang, A.M.; Saidian, A.; Magi-Galluzzi, C.; Nix, J.W.; Rais-Bahrami, S. Single-port robotic partial and radical nephrectomies for renal cortical tumors: Initial clinical experience. J. Robot. Surg. 2020, 14, 773–780. [Google Scholar] [CrossRef]
- Glaser, Z.A.; Burns, Z.R.; Fang, A.M.; Saidian, A.; Magi-Galluzzi, C.; Nix, J.W.; Rais-Bahrami, S. Single- versus multi-port robotic partial nephrectomy: A comparative analysis of perioperative outcomes and analgesic requirements. J. Robot. Surg. 2022, 16, 695–703. [Google Scholar] [CrossRef]
- Pellegrino, A.A.; Chen, G.; Morgantini, L.; Calvo, R.S.; Crivellaro, S. Simplifying Retroperitoneal Robotic Single-port Surgery: Novel Supine Anterior Retroperitoneal Access. Eur. Urol. 2023, 84, 223–228. [Google Scholar] [CrossRef]
- Billah, M.; Sheckley, F.; Nguyen, J.; Iarajuli, T.; Raver, M.; Rudnick, B.; Ahmed, M. Single Port Modified Partial Nephrectomy: Novel Simultaneous Access to Peritoneal and Retroperitoneal Partial Nephrectomy, Initial Clinical Experience. J. Endourol. 2024, 38, 444–449. [Google Scholar] [CrossRef]
- Bang, S.; Cho, H.J.; Ha, U.S.; Lee, J.Y.; Hong, S.H. Retroperitoneal Single-Port Robot-Assisted Nephroureterectomy with Bladder Cuff Excision: Initial Experience and Description of the Technique. J. Clin. Med. 2023, 12, 6091. [Google Scholar] [CrossRef]
- Pellegrino, A.A.; Mima, M.; Crivellaro, S. Application of the single-port robotic platform during radical nephroureterectomy for upper tract urothelial carcinoma: Feasibility of the single-port robot in the multi-quadrant setting. Transl. Androl. Urol. 2023, 12, 1469–1474. [Google Scholar] [CrossRef] [PubMed]
- Patel, M.N.; Aboumohamed, A.; Hemal, A. Does transition from the da Vinci Si to Xi robotic platform impact single-docking technique for robot-assisted laparoscopic nephroureterectomy? BJU Int. 2015, 116, 990–994. [Google Scholar] [CrossRef] [PubMed]
Surgery Type | Author | Year | Journal | Description/Objective | Study Design | # Patients |
---|---|---|---|---|---|---|
Prostatectomy | Kaouk et al. [9] | 2014 | European Urology | The first clinical investigation of single-port robotic surgery for urologic procedures | Single-institution prospective case series | 19 (11 RARP) |
Abeza et al. [10] | 2020 | Journal of Endourology | A description and comparison of outcomes between two distinct methods for adopting SP-RARP by two experienced surgeons | Two-institution prospective cohort study | 74 (34 and 40) | |
Moschovas et al. [11] | 2022 | Journal of Endourology | Assesses the outcomes and factors influencing the initial learning curve of single-port robot-assisted radical prostatectomy | Single-institution retrospective cohort study | 100 | |
Noh et al. [12] | 2022 | Journal of Endourology | A comparison of a series of MP-RARPs and SP-RARPs performed by a single surgeon | Single-institution retrospective cohort study | 40 SP-RARP, 129 MP-RARP | |
Zeinab et al. [13] | 2023 | Urology | A comparison of outcomes between extraperitoneal and transperitoneal SP-RARP | Multi-institution retrospective cohort study | 476 (238 per arm post-matching) |
Surgery Type | Author | Year | Journal | Description/Objective | Study Design | # Patients |
---|---|---|---|---|---|---|
Cystectomy | Kaouk et al. [25] | 2019 | BJU International | An initial description and evaluation of outcomes of a single-port technique for single-port RARC with intracorporal diversion and PLND | Single-institution prospective case series | 4 |
Zhang et al. [27] | 2020 | Translational Andrology and Urology | An initial description and evaluation of outcomes of a single-port technique for single-port RARC with intracorporal diversion | Single-institution prospective case series | 4 | |
Gross et al. [29] | 2021 | Journal of Endourology | Aomparison of outcomes and analgesic requirements between SP- and MP-RARC with urinary diversion | Single-institution retrospective cohort study | 96 (49 MP, 47 SP) | |
Ali et al. [30] | 2022 | Journal of Endourology | An evaluation of perioperative outcomes between SP- and MP-RARC with intracorporal diversion | Single-institution prospective cohort study | 34 (20 MP, 14 SP post-matching) | |
Fang et al. [26] | 2024 | Journal of Endourology | An evaluation of perioperative outcomes between SP- and MP-RARC with intracorporal diversion | Single-institution retrospective cohort study | 36 (24 MP, 12 SP post-matching) |
Surgery Type | Author | Year | Journal | Description/Objective | Study Design | # Patients |
---|---|---|---|---|---|---|
Radical and Partial Nephrectomy | Fang et al. [37] | 2020 | Journal of Robotic Surgery | An evaluation of the initial experience, techniques, and perioperative outcomes of SP-RAPN and SP RARN | Single-institution retrospective case series | 16 (13 PN, 3 RN) |
Glaser et al. [38] | 2022 | Journal of Robotic Surgery | A comparison of outcomes and analgesic requirements between SP- and MP-RAPN | Single-institution retrospective cohort study | 78 (52 MP, 26 SP) | |
Okhawere et al. [35] | 2022 | Journal of Endourology | A comparison of perioperative outcomes between SP- and MP-RAPN | Multi-institution prospective cohort study | 1726 (1578 MP, 148 SP) | |
Pellegrino et al. [39] | 2023 | European Urology | An evaluation of a novel supine anterior retroperitoneal access technique for SP surgery including PN, RN, RNU, and pyeloplasty | Single-institution prospective cohort study | 18 (12 PN, 2 RN, 2 RNU, 2 pyeloplasty) | |
Rich et al. [33] | 2023 | European Urology Focus | A comparison of transperitoneal vs. retroperitoneal SP-RAPN | Multi-institution prospective cohort study | 219 | |
Nguyen et al. [36] | 2024 | Journal of Endourology | An evaluation of perioperative, oncological, and functional outcomes between SP- and MP-RAPN | Meta-analysis | n/a | |
Billah et al. [40] | 2024 | European Urology Focus | A description and evaluation of a novel lower anterior access technique for SP-RAPN | Single-institution prospective cohort study | 78 | |
Bang et al. [41] | 2023 | Journal of Clinical Medicine | Initial experience and evaluation of retroperitoneal single-port RANU | Single-institution retrospective case series | 20 | |
Radical Nephroureterectomy |
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Omidele, O.; Elkun, Y.; Connors, C.; Eraky, A.; Mehrazin, R. Narrative Review of Single-Port Surgery in Genitourinary Cancers. Cancers 2025, 17, 334. https://doi.org/10.3390/cancers17030334
Omidele O, Elkun Y, Connors C, Eraky A, Mehrazin R. Narrative Review of Single-Port Surgery in Genitourinary Cancers. Cancers. 2025; 17(3):334. https://doi.org/10.3390/cancers17030334
Chicago/Turabian StyleOmidele, Olamide, Yuval Elkun, Christopher Connors, Ahmed Eraky, and Reza Mehrazin. 2025. "Narrative Review of Single-Port Surgery in Genitourinary Cancers" Cancers 17, no. 3: 334. https://doi.org/10.3390/cancers17030334
APA StyleOmidele, O., Elkun, Y., Connors, C., Eraky, A., & Mehrazin, R. (2025). Narrative Review of Single-Port Surgery in Genitourinary Cancers. Cancers, 17(3), 334. https://doi.org/10.3390/cancers17030334