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Novel approach to bis(indolyl)methanes using nickel nanoparticles as a reusable catalyst under solvent-free conditions

Olyaei Abolfazl (Department of Chemistry, Payame Noor University, Tehran, Iran)
Vaziri Mohsen (Department of Chemistry, Payame Noor University, Tehran, Iran)
Razeghi Reza (Department of Chemistry, Payame Noor University, Tehran, Iran)
Bahareh Shams (Department of Chemistry, Payame Noor University, Tehran, Iran)
Bagheri Hasan (Department of Chemistry, Islamic Azad University, Takestan Branch, Qazvin, Iran)

A nanosized Nickel as catalyst has been developed for the electrophilic substitution reactions of indole with variousaromatic aldehydes under solvent-free conditions to afford the corresponding bis(indolyl)methanes in high to excellent yields. The described method has promising features such as no hazardous organic solvents or catalysts, short reaction time, high product yields, simple work-up procedure, reusable catalyst and easy product separation without further purification with column chromatography.

Keywords: indole, aldehyde, electrophilic substitution, Ni