Serum IgE Induced Airway Smooth Muscle Cell Remodeling Is Independent of Allergens and Is Prevented by Omalizumab
Fig 2
Disease specific increased collagen type-I deposition by ASMC.
(A) disease specific collagen type-I deposition stimulating effect of serum (n = 10) at 48 hours. (B) Inhibitory effect of Omalizumab on disease specific serum stimulated collagen type-I deposition by ASMC. (C) Signalling pathways and IgE-receptor mediation of collagen type-I deposition (n = 3). (D) The effect of allergen mix to serum induced collagen type-I deposition (n = 4). All data represent the mean±S.E.M. The optical density measurements of the deposed collagen type I for all experiments are provided as shown in S1 File.