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α-Synuclein Oligomers Induced by Docosahexaenoic Acid Affect Membrane Integrity

Figure 6

Interaction of aS/DHA oligomers with DOPG vesicles by DLS and TEM.

DLS analysis, expressed as numbers (A,B) or as intensities (C,D) and TEM images (E,F) are reported. DLS measurements of DOPG LUV (A,C) and SUV (B,D) are conducted in the absence of oligomers (continuous lines), and upon 30 min-addition of oligomers (molar ratio 1:20, light grey bars). aS/oligomers alone are represented by dashed lines. The effect induced by Triton X-100 on LUV and SUV is reported (A,B, dark grey bars). TEM images of DOPG SUV (E) or in the presence (F) of aS/DHA oligomers were taken after 30 min of incubation.

Figure 6

doi: https://doi.org/10.1371/journal.pone.0082732.g006