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Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity

Figure 2

SDHA is acetylated at 13 lysine residues.

(A) Schematic of SDHA summarizing the four domains (FAD-binding, capping, helical and C-terminal) with 13 identified acetylated residues shown in red (novel) or white (previously identified). (B) The 13 acetylated lysines were mapped on to the corresponding residues of the crystal structure of avian complex II.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0023295.g002