A Novel Immune Evasion Strategy of Candida albicans: Proteolytic Cleavage of a Salivary Antimicrobial Peptide
Figure 1
Degradation and killing potency of Hst-5.
(A) Degradation of Hst-5 by C. albicans demonstrating degradation level proportional to cell density (cells/ml). (B) Decrease in the percent Integrated Density Value (IDV) of the intact Hst-5 (upper band) (P<0.02) and increase in density of degradation product (P<0.0001) (lower band). (C) Percent killing demonstrating significant killing + of C. albicans at 1×106 cells/ml density correlating with no degradation + at that cell density; whereas no killing* at 2×109 cells/ml correlates with significant degradation*. Error bars indicate the standard errors of the means.