Antimicrobial peptides modulate long-term memory
Fig 2
DptB is required for long-term memory.
(A) DptB expression measured by RT-qPCR after male courtship suppression paradigm: 1X training, 2X training, 3X training, and 3X training with decapitated females (left). DptB expression measured by RT-qPCR 1 hour or 4 hours after associative appetitive memory paradigm (right). The data are mean of three technical repeats. (B) Knocking out DptB significantly reduces long-term memory. Long-term memory (24 hours after training) and short-term memory (15 minutes after training) of DptB null flies. Long-term memory deficit of DptB null flies is rescued by a DptB genomic construct or expression of HA-tagged DptB in head fat body. The dots represent individual memory index of outliers. (C) Removal of DptB impairs long-term appetitive memory. The data are plotted as mean ± SEM. Statistical analysis was performed using unpaired two-tailed t-test and (*) P ≤ 0.05, (**) P≤0.01, (***) P≤0.001 and (ns) not significant.