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Multifactorial Analysis of Prognostic Factors and Survival Rates Among 706 Mucosal Melanoma Patients

  • Melanomas
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The hypothesis that mucosal melanomas from different anatomic sites would have different prognostic features and survival outcome was tested in a multifactorial analysis.

Methods

Complete clinical and pathological information from 706 mucosal melanoma patients from different anatomical sites was compared for overall survival (OS) and prognostic factors.

Results

Mucosal melanomas arising from different anatomical sites did not have any significant differences in OS in a multivariate analysis (p = 0.721). Among all 706 stage I–IV mucosal melanoma patients, depth of tumor invasion (p < 0.001), number of lymph node metastases (p < 0.001), and sites of distant metastases (p < 0.001) were independent prognostic factors for OS; among 543 stage I–III patients, depth of tumor invasion (p < 0.001) and number of lymph node metastases (p < 0.001) were independent prognostic factors for OS; and among 547 stage IV patients, depth of tumor invasion (p = 0.009), number of lymph node metastases (p < 0.001), and combined distant metastases and elevation of serum lactate dehydrogenase (LDH; p < 0.001) were independent prognostic factors for OS. The presence of c-KIT or BRAF mutations was not predictive of survival.

Conclusions

This is the first large-scale study comparing outcomes of mucosal melanomas from different anatomic sites in a multifactorial analysis. There were no significant survival differences among mucosal melanomas arising at different sites when matched for staging and prognostic and molecular factors, thus rejecting our hypothesis. We concluded that prognostic characteristics of mucosal melanomas can be staged as a single histological group, regardless of the anatomic site of the primary tumor.

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References

  1. Bishop KD, Olszewski AJ. Epidemiology and survival outcomes of ocular and mucosal melanomas: a population-based analysis. Int J Cancer. 2014;15:134:2961–71.

    Article  CAS  Google Scholar 

  2. Lian B, Cui C, Zhou l, et al. The Natural history and patterns of metastases from mucosal melanoma: an analysis of 706 prospectively-followed patients. Ann Oncol. 2017;28:868–73.

    PubMed  CAS  Google Scholar 

  3. Balch CM, Gershenwald JE, Soong SJ, et al. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol. 2009;27(36):6199–206.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Lian B, Si L, Cui C, et al. Phase II randomized trial comparing high-dose IFN-alpha2b with temozolomide plus cisplatin as systemic adjuvant therapy for resected mucosal melanoma. Clin Cancer Res. 2013;19:4488–98.

    Article  PubMed  CAS  Google Scholar 

  5. Koivunen P, Bäck L, Pukkila M, et al. Accuracy of the current TNM classification in predicting survival in patients with sinonasal mucosal melanoma. Laryngoscope. 2012;122:1734–8.

    Article  PubMed  Google Scholar 

  6. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457.

    Article  Google Scholar 

  7. Cox DR. Regression model and life tables. J R Stat Soc B 1972;34:187.

    Google Scholar 

  8. Balch CM, Soong SJ, Gershenwald JE, et al. Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol. 2001;19(16):3622–34.

    Article  PubMed  CAS  Google Scholar 

  9. Heppt MV, Roesch A, Weide B, et al. Prognostic factors and treatment outcomes in 444 patients with mucosal melanoma. Eur J Cancer. 2017;7(81):36–44.

    Article  Google Scholar 

  10. Keller DS, Thomay AA, Gaughan J, et al. Outcomes in patients with mucosal melanomas. J Surg Oncol. 2013;108(8):516–20.

    Article  PubMed  Google Scholar 

  11. Mehra T, Grözinger G, Mann S et al. Primary localization and tumor thickness as prognostic factors of survival in patients with mucosal melanoma. PLoS ONE 2014;9(11):e112535.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. Hicks MJ, Flaitz CM. Oral mucosal melanoma: epidemiology and pathobiology. Oral Oncol. 2000;36:152–69.

    Article  PubMed  CAS  Google Scholar 

  13. Buchanan DJ, Schlaerth J, Kurosaki T. Primary vaginal melanoma: thirteen-year disease-free survival after wide local excision and review of recent literature. Am J Obstet Gynecol. 1998;178:1177–84.

    Article  PubMed  CAS  Google Scholar 

  14. Balch CM, Wilkerson JA, Murad TM, et al. The prognostic significance of ulceration of cutaneous melanoma. Cancer. 1980; 45:3012–17.

    Article  PubMed  CAS  Google Scholar 

  15. Balch CM, Gershenwald JE, Soong SJ,et al. Multivariate analysis of prognostic factors among 2,313 patients with stage III melanoma: comparison of nodal micrometastases versus macrometastases. J Clin Oncol. 2010; 28(14): 2452–59.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Frumovitz M, Etchepareborda M, Sun CC, et al. Primary malignant melanoma of the vagina. Obstet Gynecol. 2010;116:1358–65.

    Article  PubMed  Google Scholar 

  17. Sugiyama VE, Chan JK, Shin JY, et al. Vulvar melanoma: a multi-variable analysis of 644 patients. Obstet Gynecol. 2007;110:296–301.

    Article  PubMed  Google Scholar 

  18. Iddings DM, Fleisig AJ, Chen SL, et al. Practice patterns and outcomes for anorectal melanoma in the USA, reviewing three decades of treatment: is more extensive surgical resection bene cial in all patients? Ann Surg Oncol. 2010;17:40–44.

    Article  PubMed  Google Scholar 

  19. Perez DR, Trakarnsanga A, Shia J, et al. Locoregional lymphadenectomy in the surgical management of anorectal melanoma. Ann Surg Oncol. 2013;20(7):2339–44.

    Article  PubMed  PubMed Central  Google Scholar 

  20. DeMatos P, Tyler DS, Seigler HF. Malignant melanoma of the mucous membranes: a review of 119 cases. Ann Surg Oncol. 1998;5:733–42.

    Article  PubMed  CAS  Google Scholar 

  21. Thompson LD, Wieneke JA, Miettinen M. Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic study of 115 cases with a proposed staging system. Am J Surg Pathol. 2003;27:594–611.

    Article  PubMed  Google Scholar 

  22. Manola J, Atkins M, Ibrahim J, et al. Prognostic factors in metastatic melanoma: a pooled analysis of Eastern Cooperative Oncology Group trials. J Clin Oncol. 2000;18:3782–93.

    Article  PubMed  CAS  Google Scholar 

  23. Kong Y, Si L, Zhu Y et al. Large-scale analysis of KIT aberrations in Chinese patients with melanoma. Clin Cancer Res. 2011;17(7):1684–91.

    Article  PubMed  CAS  Google Scholar 

  24. Amit M, Tam S, Abdelmeguid AS, et al. Mutation status among patients with sinonasal mucosal melanoma and its impact on survival. Br J Cancer. 2017;116(12):1564–71.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Acknowledgments

The authors wish to thank the patients and their families for making this study possible.

Funding

This work was supported by grants from Beijing Talents Fund (2016000021469G186, 2016000021223ZK18, 2014000021223ZK26), Beijing Municipal Administration of Hospitals Incubating Program (PX2017042), National Natural Science Foundation of China (81672696), Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201603), and Beijing Municipal Science and Technology Commission (Z151100003915074).

Author information

Author notes

  1. ChuanLiang Cui and Bin Lian have contributed equally to this work and are the co-first authors.

Authors and Affiliations

  1. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, Beijing, China

    ChuanLiang Cui MD, Bin Lian MD, Li Zhou MD, ZhiHong Chi MD, Lu Si MD, XiNan Sheng MD, Yan Kong PhD, BiXia Tang MD, LiLi Mao MD, Xuan Wang MD, SiMing Li MD, Jie Dai PhD, XieQiao Yan MD, Xue Bai MD & Jun Guo MD, PhD

  2. Yunnan Cancer Hospital, Kunming, China

    Xin Song MD

  3. SUN YAT-SEN University Cancer Center, Guangzhou, China

    XiaoShi Zhang MD

  4. The First Hospital of Jilin University, Changchun, China

    Di Wu MD

  5. University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Charles M. Balch MD

Authors
  1. ChuanLiang Cui MD
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  2. Bin Lian MD
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  3. Li Zhou MD
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  4. Xin Song MD
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  5. XiaoShi Zhang MD
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  6. Di Wu MD
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  7. ZhiHong Chi MD
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  8. Lu Si MD
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  9. XiNan Sheng MD
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  10. Yan Kong PhD
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  11. BiXia Tang MD
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  12. LiLi Mao MD
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  13. Xuan Wang MD
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  14. SiMing Li MD
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  15. Jie Dai PhD
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  16. XieQiao Yan MD
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  17. Xue Bai MD
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  18. Charles M. Balch MD
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  19. Jun Guo MD, PhD
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Contributions

Conception and design: JG, CMB, CLC, BL. Provision of study materials or patients: CLC, BL, LZ, XS, XSZ, DW. Collection and assembly of data: JG, CLC, BL, LZ, XS, XSZ, DW, ZHC, LS, XNS, YK, BXT, LLM, XW, SML, JD, XQY, XB. Data analysis and interpretation: JG, CMB, CLC, BL, LZ. Manuscript writing: All authors. Final approval of the manuscript submitted for publication: All authors.

Corresponding authors

Correspondence to Charles M. Balch MD or Jun Guo MD, PhD.

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Disclosures

ChuanLiang Cui, Bin Lian, Li Zhou, Xin Song, XiaoShi Zhang, Di Wu, ZhiHong Chi, Lu Si, XiNan Sheng, Yan Kong, BiXia Tang, LiLi Mao, Xuan Wang, SiMing Li, Jie Dai, XieQiao Yan, Xue Bai, Charles M. Balch, and Jun Guo have declared no conflicts of interest.

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Cui, C., Lian, B., Zhou, L. et al. Multifactorial Analysis of Prognostic Factors and Survival Rates Among 706 Mucosal Melanoma Patients. Ann Surg Oncol 25, 2184–2192 (2018). https://doi.org/10.1245/s10434-018-6503-9

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  • DOI: https://doi.org/10.1245/s10434-018-6503-9

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