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Nanomedicine Scale-up Technologies: Feasibilities and Challenges

  • Mini-Review
  • Theme: Translational Application of Nano Delivery Systems: Emerging Cancer Therapy
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Abstract

Nanomedicine refers to biomedical and pharmaceutical applications of nanosized cargos of drugs/vaccine/DNA therapeutics including nanoparticles, nanoclusters, and nanospheres. Such particles have unique characteristics related to their size, surface, drug loading, and targeting potential. They are widely used to combat disease by controlled delivery of bioactive(s) or for diagnosis of life-threatening problems in their very early stage. The bioactive agent can be combined with a diagnostic agent in a nanodevice for theragnostic applications. However, the formulation scientist faces numerous challenges related to their development, scale-up feasibilities, regulatory aspects, and commercialization. This article reviews recent progress in the method of development of nanoparticles with a focus on polymeric and lipid nanoparticles, their scale-up techniques, and challenges in their commercialization.

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Abbreviations

NME:

Nanoporous membrane extrusion

SCF:

Supercritical fluid

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ACKNOWLEDGMENTS

The authors are thankful to National Corn Growers Association (NCGA) for their research grant support to SP and post-doctoral fellowship to RP.

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Authors and Affiliations

  1. Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, 1010 West Avenue B, MSC 131, Kingsville, Texas, 78363, USA

    Rishi Paliwal & Srinath Palakurthi

  2. Harrison School of Pharmacy, Auburn, Alabama, USA

    R. Jayachandra Babu

Authors
  1. Rishi Paliwal
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  2. R. Jayachandra Babu
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  3. Srinath Palakurthi
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Corresponding author

Correspondence to Srinath Palakurthi.

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Guest Editors: Mahavir B. Chougule and Chalet Tan

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Paliwal, R., Babu, R.J. & Palakurthi, S. Nanomedicine Scale-up Technologies: Feasibilities and Challenges. AAPS PharmSciTech 15, 1527–1534 (2014). https://doi.org/10.1208/s12249-014-0177-9

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