A steady—state enzyme kinetics modeling system
Authors: 
Nancy Schatz, Chan F. LamAuthors Info & Claims
Pages 789 - 790
Abstract
A technique is presented to generate rate equations for random enzymatic mechanisms in a systematic manner. The generation of constraint equations arrived from the principle of detailed balance is also discussed. The rate constants of the reaction mechanisms are then estimated by a stepwise least squares algorithm.
References
[1]
Draper, N. R. and H. Smith. Applied Regression Analysis, New York, John Wiley & Sons, Inc., 1966, p. 86-103, 263-304.
[2]
Hearon, J. Z. "The Kinetics of Linear Systems with Special Reference to Periodic Reactions". Bul. Math. Biophys. 15:121-141, 1953.
[3]
Hearon, J. Z., S. A. Bernard, S. L. Friers, D. J. Botts, and M. F. Morales, "Enzyme Kinetics". In The Enzymes, edited by P. D. Boyer, H. A. Lardy, and K. Myrback. New York Academic Press, Inc., 1959, 2nd edition, Vol. 1, p. 62-67.
[4]
King, E. L. and C. Altman. "A Schematic Method of Deriving the Rate Laws for Enzyme-Catalyzed Reactions". J. Phys. Chem. 60:1375-1378, 1956.
[5]
Lam, C. F. and D. G. Priest. "Enzyme Kinetics- A Systematic Generation of Valid King-Altman Patterns". Biophys. J. 12:248-256, 1972.
Index Terms
- A steady—state enzyme kinetics modeling system
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Information
Published In
January 1974
839 pages
Sponsors
- ACM: Association for Computing Machinery
- AIIE: AIIE
- ORSA: Operations Research Society of America
- SCS: Society for Computer Simulation
- TIMS
- SIGSIM: ACM Special Interest Group on Simulation and Modeling
- IEEE: Institute of Electrical and Electronics Engineers
- SHARE: SHARE
Publisher
Winter Simulation Conference
Publication History
Published: 01 January 1974
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Overall Acceptance Rate 3,413 of 5,075 submissions, 67%
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