The Intermittent Theta-Burst Stimulation Induces a Lasting Motor Learning Improvement In Healthy Young Subjects.
Pages 187 - 191
Abstract
Non-invasive brain stimulation (NIBS) paradigms have been used to modulate plasticity in the human motor cortex to enhance motor learning. However, our understanding of the lasting effects of different NIBS protocols on motor learning task performance remains limited. This study aimed to investigate whether cortical plasticity induced by NIBS protocols targeting the primary motor cortex (M1) has a lasting impact on motor learning ability, as assessed by the serial reaction time task (SRTT). Eighteen participants were recruited and underwent high-frequency repetitive transcranial magnetic stimulation (rTMS) at 20Hz, intermittent theta burst stimulation (iTBS), or sham stimulation over the right M1. SRTT performance was evaluated before, immediately after, and 1 day following a single stimulation session. The results revealed significant improvements in motor learning ability in both the iTBS and 20Hz rTMS groups after the intervention, with the iTBS group exhibiting a superior motor learning effect (P = 0.017). Furthermore, significant improvement in sequence learning was observed in the iTBS group at follow-up (P < 0.001), and iTBS showed superior efficacy in inducing lasting motor learning improvement compared to the sham group (P < 0.001). This study demonstrates that iTBS can induce a lasting motor learning improvement in healthy young individuals. Furthermore, iTBS may extend its unique advantages to a broader population experiencing difficulties with motor learning, and provide new insights for exploring and refining innovative therapeutic interventions aimed at improving and sustaining cognitive and motor function.
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- The Intermittent Theta-Burst Stimulation Induces a Lasting Motor Learning Improvement In Healthy Young Subjects.
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November 2024
284 pages
ISBN:9798400718274
DOI:10.1145/3707127
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Published: 06 February 2025
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ICBBE 2024
ICBBE 2024: 2024 11th International Conference on Biomedical and Bioinformatics Engineering
November 8 - 11, 2024
Osaka, Japan
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