Enhancing Adaptive Physics Refinement Simulations Through the Addition of Realistic Red Blood Cell Counts
Authors: 
Sayan Roychowdhury, Samreen T. Mahmud, Aristotle Martin, Peter Balogh, Daniel F. Puleri, John Gounley, Erik W. Draeger, Amanda RandlesAuthors Info & Claims
Article No.: 41, Pages 1 - 13
Abstract
Simulations of cancer cell transport require accurately modeling mm-scale and longer trajectories through a circulatory system containing trillions of deformable red blood cells, whose intercellular interactions require submicron fidelity. Using a hybrid CPU-GPU approach, we extend the advanced physics refinement (APR) method to couple a finely-resolved region of explicitly-modeled red blood cells to a coarsely-resolved bulk fluid domain. We further develop algorithms that: capture the dynamics at the interface of differing viscosities, maintain hematocrit within the cell-filled volume, and move the finely-resolved region and encapsulated cells while tracking an individual cancer cell. Comparison to a fully-resolved fluid-structure interaction model is presented for verification. Finally, we use the advanced APR method to simulate cancer cell transport over a mm-scale distance while maintaining a local region of RBCs, using a fraction of the computational power required to run a fully-resolved model.
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MP4 File - SC23 paper presentation recording for "Enhancing Adaptive Physics Refinement Simulations Through the Addition of Realistic Red Blood Cell Counts"
SC23 paper presentation recording for "Enhancing Adaptive Physics Refinement Simulations Through the Addition of Realistic Red Blood Cell Counts", by Sayan Roychowdhury, Samreen T. Mahmud, Aristotle Martin, Peter Balogh, Daniel F. Puleri, John Gounley, Erik W. Draeger and Amanda Randles
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Index Terms
- Enhancing Adaptive Physics Refinement Simulations Through the Addition of Realistic Red Blood Cell Counts
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Published In
November 2023
1428 pages
ISBN:9798400701092
DOI:10.1145/3581784
- Chair:
- Dorian Arnold,
- Program Chair:
- Rosa M Badia,
- Program Co-chair:
- Kathryn Mohror
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Published: 11 November 2023
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