Construction of Dysregulated lncRNA-Associated ceRNA Network in Atrial Fibrillation
Pages 129 - 133
Abstract
Enough evidence has revealed that competing endogenous RNAs (ceRNAs) activity of long non-coding RNAs (lncRNAs) plays an important role in pathological processes of human diseases including cardiovascular diseases. However, the role of lncRNA in atrial fibrillation (AF) and their implications still remain unclear to date. In this study, lncRNA-mRNA network related to AF was constructed based on the ceRNA theory. We first obtained lncRNAs with topological characteristics in the lncRNA-mRNA network. We then construct a co-expression network to identify the lncRNA-associated functions, and the mRNAs in the network were analyzed for the enriched pathways which showed that the pathways were related to AF. We then analyzed the dysregulation of lncRNA-mRNA in ceRNA network and obtained three lncRNAs as hub lncRNAs. The obtained results indicate that lncRNAs might exert the pathogenesis of AF. This might help in the understanding of molecular mechanisms of lncRNA in AF, providing novel lncRNAs as potential biomarkers and/or therapeutic targets.
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Published In
May 2021
293 pages
ISBN:9781450389655
DOI:10.1145/3473258
Copyright © 2021 ACM.
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Association for Computing Machinery
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Publication History
Published: 11 December 2021
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- Refereed limited
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- National Natural Science Foundation of China
- Key R&D Project of Sichuan Province
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ICBBT '21
ICBBT '21: 2021 13th International Conference on Bioinformatics and Biomedical Technology
May 21 - 23, 2021
Xi'an, China
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