The role of depression in mild cognitive impairment through the analysis with artificial neural networks
Authors: 
Virginia Mato-Abad, Isabel Jiménez, Francisco Cedrón Santaeufemia, Juan M. Pías-Peleteiro, Purificación Cacabelos, Sara Álvarez González, José Aldrey, Sonia Suárez Garaboa, Santiago Rodríguez-YáñezAuthors Info & Claims
Article No.: 46, Pages 1 - 4
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Abstract
Depression and cognitive impairment are intimately associated, especially in elderly people. However, the association between depression and mild cognitive impairment (MCI) is complex. Several authors have found that depression is associated with a subtype of frontal cognitive impairment of possible vascular cause that mostly do not progress to dementia in contrast with other authors that associate depression in MCI as a risk factor for progression to Alzheimer's Disease. To contribute to the understanding of the evolution and prognosis of these two diseases, this study's primary intent was to explore the ability of artificial neural networks (ANNs) to identify an MCI subtype associated with depression as an entity by using the scores of an extensive neurological examination. The sample consisted of 74 patients classified into two groups: 33 MCI with depression and 41 MCI without depression. According to our results, ANNs can identify an MCI that is highly associated with depression distinguishable from the non-depressed MCI patients (accuracy=97%, sensitivity= 96%, specificity=97%). These results provide data in favor of a cognitive frontal profile of patients associated with depression, distinct and distinguishable from other cognitive impairments. Therefore, it should be considered in the classification of MCI subtypes for future research, including depression as an essential variable in the classification of a patient with cognitive impairment.
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Published In
October 2018
274 pages
ISBN:9781450365369
DOI:10.1145/3279996
- Conference Chair:
- Juan Alfonso Lara Torralbo,
- Program Chair:
- Shadi A. Aljawarneh
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Published: 01 October 2018
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DATA '18
DATA '18: International Conference on Data Science, E-learning and Information Systems 2018
October 1 - 2, 2018
Madrid, Spain
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