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Plant phenols and autophagy

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Abstract

Many plant phenols (stilbenes, curcumins, catechins, flavonoids, etc.) are effective antioxidants and protect cells during oxidative stress. Extensive clinical studies on the potential of phenolic compounds for treatment of cardiovascular, neurodegenerative, oncological, and inflammatory diseases are now being conducted. In addition to direct antioxidant effect, plant phenols may provide a protective effect via activation of the Keap1/Nrf2/ARE redox-sensitive signaling system and regulation of autophagy. In this review, mechanisms of effects of the most common plant phenols on autophagy are presented.

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Abbreviations

Akt:

protein kinase B (or PKB)

AMPK:

AMP-activated protein kinase

ARE:

antioxidant respons(iv)e element

Atg:

AuTophaGy-related genes

BAX:

Bcl-2-associated X protein

Bcl-2:

B-cell lymphoma 2

BNIP3:

Bcl-2/adenovirus E1B nineteen kDa interacting protein 3

Cu,Zn-SOD:

copper- and zinc-containing superoxide dismutase

eIF4E-BP1:

eukaryotic initiation factor 4E binding protein 1

ER:

endoplasmic reticulum

ERK1/2:

extracellular signal-regulated protein kinase 1/2

FOXO1:

forkhead box protein O1

GABARAP:

gamma-aminobutyric acid receptor-associated protein

HIF-1α:

hypoxia-inducible factor 1α

HMGB1:

high mobility group box 1

IRE1:

inositol requiring kinase 1

JAK:

Janus kinase

JNK:

c-Jun N-terminal kinases

Keap1:

Kelch-like ECH-associating protein 1

LC3:

microtubule-associated protein 1A/1B-light chain 3

LDL:

low-density lipoproteins

MAPK:

mitogen-activated protein kinases

Mn-SOD:

manganese-dependent superoxide dismutase

mTOR:

mammalian target of rapamycin (serine/threonine protein kinase)

mTORC1/2:

mammalian target of rapamycin complex 1/2

Nrf2:

NF-E2-related factor 2

p62/SQSTM1:

ubiquitin-binding protein p62, or sequestosome 1

p70S6K:

p70S6 kinase (serine/threonine protein kinase)

PERK:

protein kinase-like endoplasmic reticulum kinase

PI3K:

phosphatidylinositol 3-kinase

Ras:

rat sarcoma protein

ROS:

reactive oxygen species

SIRT1:

sirtuin 1

TSC2:

tuberous sclerosis complex 2

ULK1/ULK2:

Unc51-like kinase 1/2 (serine/threonine protein kinase)

Vps34:

vacuolar protein sorting-associated protein 34 (PI3K class III)

Wnt:

wingless/integration signaling pathway

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Authors and Affiliations

  1. Research Institute of Experimental and Clinical Medicine, Novosibirsk, 630117, Russia

    N. K. Zenkov, A. V. Chechushkov, P. M. Kozhin & E. B. Menshchikova

  2. Novosibirsk State Pedagogical University, 630126, Novosibirsk, Russia

    N. V. Kandalintseva

  3. Belarusian State University, 220030, Minsk, Belarus

    G. G. Martinovich

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  1. N. K. Zenkov
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Original Russian Text © N. K. Zenkov, A. V. Chechushkov, P. M. Kozhin, N. V. Kandalintseva, G. G. Martinovich, E. B. Menshchikova, 2016, published in Biokhimiya, 2016, Vol. 81, No. 4, pp. 429-447.

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Zenkov, N.K., Chechushkov, A.V., Kozhin, P.M. et al. Plant phenols and autophagy. Biochemistry Moscow 81, 297–314 (2016). https://doi.org/10.1134/S0006297916040015

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