A pediatric brain structure atlas from T1-weighted MR images

10 March 2006 A pediatric brain structure atlas from T1-weighted MR images

Zuyao Y. Shan, Carlos Parra, Qing Ji, Robert J. Ogg, Yong Zhang, Fred H. Laningham, Wilburn E. Reddick

Author Affiliations +

Proceedings Volume 6141, Medical Imaging 2006: Visualization, Image-Guided Procedures, and Display; 614126 (2006) https://doi.org/10.1117/12.651922
Event: Medical Imaging, 2006, San Diego, California, United States

Abstract

In this paper, we have developed a digital atlas of the pediatric human brain. Human brain atlases, used to visualize spatially complex structures of the brain, are indispensable tools in model-based segmentation and quantitative analysis of brain structures. However, adult brain atlases do not adequately represent the normal maturational patterns of the pediatric brain, and the use of an adult model in pediatric studies may introduce substantial bias. Therefore, we proposed to develop a digital atlas of the pediatric human brain in this study. The atlas was constructed from T1 weighted MR data set of a 9 year old, right-handed girl. Furthermore, we extracted and simplified boundary surfaces of 25 manually defined brain structures (cortical and subcortical) based on surface curvature. Higher curvature surfaces were simplified with more reference points; lower curvature surfaces, with fewer. We constructed a 3D triangular mesh model for each structure by triangulation of the structure's reference points. Kappa statistics (cortical, 0.97; subcortical, 0.91) indicated substantial similarities between the mesh-defined and the original volumes. Our brain atlas and structural mesh models (www.stjude.org/BrainAtlas) can be used to plan treatment, to conduct knowledge and modeldriven segmentation, and to analyze the shapes of brain structures in pediatric patients.

Citation Download Citation

Zuyao Y. Shan, Carlos Parra, Qing Ji, Robert J. Ogg, Yong Zhang, Fred H. Laningham, and Wilburn E. Reddick "A pediatric brain structure atlas from T1-weighted MR images", Proc. SPIE 6141, Medical Imaging 2006: Visualization, Image-Guided Procedures, and Display, 614126 (10 March 2006); https://doi.org/10.1117/12.651922

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Brain

Magnetic resonance imaging

Neuroimaging

Image segmentation

3D modeling

Visualization

Shape analysis

Show All Keywords

Keywords/Phrases

Search In:

Publication Years