Method of simulation and visualization of FDG metabolism based on VHP image

12 April 2005 Method of simulation and visualization of FDG metabolism based on VHP image

Yunfeng Cui, Jing Bai

Author Affiliations +

Proceedings Volume 5744, Medical Imaging 2005: Visualization, Image-Guided Procedures, and Display; (2005) https://doi.org/10.1117/12.593312
Event: Medical Imaging, 2005, San Diego, California, United States

Abstract

FDG ([¹⁸F] 2-fluoro-2-deoxy-D-glucose) is the typical tracer used in clinical PET (positron emission tomography) studies. The FDG-PET is an important imaging tool for early diagnosis and treatment of malignant tumor and functional disease. The main purpose of this work is to propose a method that represents FDG metabolism in human body through the simulation and visualization of ¹⁸F distribution process dynamically based on the segmented VHP (Visible Human Project) image dataset. First, the plasma time-activity curve (PTAC) and the tissues time-activity curves (TTAC) are obtained from the previous studies and the literatures. According to the obtained PTAC and TTACs, a set of corresponding values are assigned to the segmented VHP image, Thus a set of dynamic images are derived to show the ¹⁸F distribution in the concerned tissues for the predetermined sampling schedule. Finally, the simulated FDG distribution images are visualized in 3D and 2D formats, respectively, incorporated with principal interaction functions. As compared with original PET image, our visualization result presents higher resolution because of the high resolution of VHP image data, and show the distribution process of ¹⁸F dynamically. The results of our work can be used in education and related research as well as a tool for the PET operator to design their PET experiment program.

Citation Download Citation

Yunfeng Cui and Jing Bai "Method of simulation and visualization of FDG metabolism based on VHP image", Proc. SPIE 5744, Medical Imaging 2005: Visualization, Image-Guided Procedures, and Display, (12 April 2005); https://doi.org/10.1117/12.593312

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