8 March 2019Minimally invasive intraventricular ultrasound: design and instrumentation towards a miniaturized ultrasound-guided focused ultrasound probe
Micah Belzberg,1 Francisco Chavez,2 Kah Timothy Xiong,2 Kyle Morrison,2 Nao Gamo,1 Stephen Restaino,3 Rajiv Iyer,1 Mari Groves,1 Nitish Thakor,1 Henry Brem,1 Alan Cohen,1 Amir Manbachi1,4
1Johns Hopkins Univ. (United States) 2Sonic Concepts, Inc. (United States) 3Maryland Development Ctr. (United States) 4Johns Hopkins Armstrong Institute for Patient Safety and Quality (United States)
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Neurosurgery typically requires craniectomy and meticulous dissection to achieve sufficient exposure for subsequent surgical intervention. This highly invasive process requires hours of operating time, long recovery periods and leaves patients with visible surgical scars. Non-invasive high-intensity focused ultrasound (HIFU) has shown some promise yet remains challenged by the attenuation of ultrasonic waves while passing through the skull. Consequently, the clinical impact of this technology remains limited, particularly in the treatment of neuro-oncology. In order to compensate for acoustic attenuation, excessive use of power for HIFU devices has been investigated, although it is undesirable from a regulatory and patient safety standpoint. Here, we report the design and development of a novel HIFU device prototype for neurologic lesion ablation. This device concept is envisioned to access the ventricular space via a minimally invasive ventriculostomy, allowing ultrasound to reach targets deep in the brain, while eliminating the need for high power to penetrate the skull.
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Micah Belzberg, Francisco Chavez, Kah Timothy Xiong, Kyle Morrison, Nao Gamo, Stephen Restaino, Rajiv Iyer, Mari Groves, Nitish Thakor, Henry Brem, Alan Cohen, Amir Manbachi, "Minimally invasive intraventricular ultrasound: design and instrumentation towards a miniaturized ultrasound-guided focused ultrasound probe," Proc. SPIE 10951, Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling, 109512Y (8 March 2019); https://doi.org/10.1117/12.2513150