The fusion of pre-operative 3D magnetic resonance (MR) images with real-time 3D ultrasound (US) images can be the most beneficial way to guide minimally invasive cardiovascular interventions without radiation. Previously, we addressed this topic through a strategy to segment the left ventricle (LV) on interventional 3D US data using a personalized shape prior obtained from a pre-operative MR scan. Nevertheless, this approach was semi-automatic, requiring a manual alignment between US and MR image coordinate systems. In this paper, we present a novel solution to automate the abovementioned pipeline. In this sense, a method to automatically detect the right ventricular (RV) insertion point on the US data was developed, which is subsequently combined with pre-operative annotations of the RV position in the MR volume, therefore allowing an automatic alignment of their coordinate systems. Moreover, a novel strategy to ensure a correct temporal synchronization of the US and MR models is applied. Finally, a full evaluation of the proposed automatic pipeline is performed. The proposed automatic framework was tested in a clinical database with 24 patients containing both MR and US scans. A similar performance between the proposed and the previous semi-automatic version was found in terms of relevant clinical measurements. Additionally, the automatic strategy to detect the RV insertion point showed its effectiveness, with a good agreement against manually identified landmarks. The proposed automatic method showed high feasibility and a performance similar to the semi-automatic version, reinforcing its potential for normal clinical routine.
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