Therapeutic iminoboronate-based polymersomes with a Cu(ii)-mediated Fenton reaction-enhanced ROS-response

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Therapeutic iminoboronate-based polymersomes with a Cu(ii)-mediated Fenton reaction-enhanced ROS-response†

Ruidong Cheng,^ab Guo Li,^a Li Fan,*^c Jinqiang Jiang

*^a and Yue Zhao

*^b

Author affiliations

* Corresponding authors

^a Key Laboratory of Syngas Conversion of Shaanxi Province, Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an, Shaanxi Province, P. R. China
E-mail: jiangjq@snnu.edu.cn

^b Departement de Chimie, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
E-mail: yue.zhao@usherbrooke.ca

^c Department of Pharmaceutical Chemistry and Analysis, School of Pharmacy, Fourth Military Medical University, Xi’an, Shaanxi Province, P. R. China
E-mail: xxfanny@fmmu.edu.cn

Abstract

Reactive oxygen species (ROS)-responsive prodrug nanoplatforms may not work efficiently due to insufficient ROS concentrations, so therapeutic polymersomes of a metallisable triamine-centered iminoboronate-functionalized amphiphilic starlike prodrug (N₃-(OEG-IBCAPE)₄) are prepared to show a Cu(II)-mediated Fenton reaction-enhanced ROS response.

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Article information

DOI: https://doi.org/10.1039/D0CC03607B
Article type: Communication
Submitted: 21 May 2020
Accepted: 02 Sep 2020
First published: 02 Sep 2020

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Chem. Commun., 2020,56, 12246-12249

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