Abstract
In this Review, we highlight some recent developments in the discovery and application of broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV); i.e., antibodies able to neutralize diverse isolates of HIV. We consider the characterization of novel bnAbs, recent data on the effects of bnAbs in vivo in humans and animal models, and the importance of both kinds of data for the application of Abs to prophylaxis and therapy and to guide vaccine design. We seek to place newly discovered bnAbs in the context of existing bnAbs, and we explore the various characteristics of the antibodies that are most desirable for different applications.
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Change history
01 February 2019
In the version of this article initially published, some of the references in Table 1 were incorrect. The correct references are as follows: in row 12, refs. 12,44 should be ref. 12; in row 16, refs. 2,17,27 should be ref. 109 (Walker, L. M. et al. Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature 477, 466–470 (2011)); in row 25, refs. 61,76 should be ref. 110 (Wu, X. et al. Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. Science 329, 856–861 (2010)); and in the bottom row, ref. 57 should be ref. 111 (Huang, J. et al. Broad and potent neutralization of HIV-1 by a gp41-specific human antibody. Nature 491, 406–412 (2012)). Those new references (109–111) should be included in the reference list. The errors have been corrected in the HTML and PDF versions of the article.
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Acknowledgements
We thank I. Wilson and W. Schief for comments on the manuscript; and L. Hangartner, C. Corbaci and B. Briney for assistance with figure preparation. Supported by the US National Institute of Allergy and Infectious Diseases (D.R.B.), IAVI (D.R.B.), the Bill and Melinda Gates Foundation (D.R.B.), the Ragon Institute (D.R.B.), the Bill & Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery (D.S.) and the United States Agency for International Development (D.S.). A full list of IAVI donors is available at https://www.iavi.org/what-we-do/partner/donors. Contributions from the International AIDS Vaccine Initiative do not necessarily reflect the views of USAID or the United States government.
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Sok, D., Burton, D.R. Recent progress in broadly neutralizing antibodies to HIV. Nat Immunol 19, 1179–1188 (2018). https://doi.org/10.1038/s41590-018-0235-7
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DOI: https://doi.org/10.1038/s41590-018-0235-7
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