[go: up one dir, main page]
More Web Proxy on the site http://driver.im/
Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Comment
  • Published:

What is ‘LDL cholesterol’?

Nature Reviews Cardiology volume 16, pages 197–198 (2019)Cite this article

Subjects

LDL cholesterol is an important contributor to the risk of coronary heart disease, and its measurement is central to evaluating the effects of lipid-modifying therapies. Several ‘LDL-cholesterol’ assays exist but their methodologies differ, leading to between-assay heterogeneity in values of ‘LDL cholesterol’. We advocate the need for awareness of the potential implications.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Circulating, apoB-containing lipoproteins and methods for quantifying ‘LDL cholesterol’.

References

  1. HPS3/TIMI55-REVEAL Collaborative Group. Effects of anacetrapib in patients with atherosclerotic vascular disease. N. Engl. J. Med. 377, 1217–1227 (2017).

    Article  Google Scholar 

  2. Boren, J. & Williams, K. J. The central role of arterial retention of cholesterol-rich apolipoprotein-B-containing lipoproteins in the pathogenesis of atherosclerosis: a triumph of simplicity. Curr. Opin. Lipidol. 27, 473–483 (2016).

    Article  CAS  Google Scholar 

  3. Kettunen, J. et al. Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition. Preprint at bioRxiv https://doi.org/10.1101/295394 (2018).

    Article  Google Scholar 

  4. Sliz, E. et al. Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment. Circulation 138, 2499–2512 (2018).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

M.V.H. is supported by a British Heart Foundation Intermediate Clinical Research Fellowship (FS/18/23/33512). M.A.-K. is supported by a Senior Research Fellowship from the National Health and Medical Research Council (NHMRC) of Australia (APP1158958) and works in a Unit that is supported by the University of Bristol and UK Medical Research Council (MC_UU_12013/1).

Author information

Authors and Affiliations

  1. Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK

    Michael V. Holmes

  2. Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK

    Michael V. Holmes

  3. Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK

    Michael V. Holmes & Mika Ala-Korpela

  4. Systems Epidemiology, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

    Mika Ala-Korpela

  5. Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland

    Mika Ala-Korpela

  6. NMR Metabolomics Laboratory, School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland

    Mika Ala-Korpela

Authors
  1. Michael V. Holmes
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mika Ala-Korpela
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Michael V. Holmes or Mika Ala-Korpela.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Holmes, M.V., Ala-Korpela, M. What is ‘LDL cholesterol’?. Nat Rev Cardiol 16, 197–198 (2019). https://doi.org/10.1038/s41569-019-0157-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41569-019-0157-6

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing