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  • Original Article
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Immune Suppression

Zinc in pharmacological doses suppresses allogeneic reaction without affecting the antigenic response

Bone Marrow Transplantation volume 33, pages 1241–1246 (2004)Cite this article

Summary:

Zinc is an essential trace element for the immune system. Previously it was shown that zinc inhibits alloreactivity. In our present in vitro experiments, it is shown that zinc maintains the antigenic potency of the host while blocking the allogeneic response. These results were observed in experiments using tetanus toxoid as a well-established recall antigen and the mixed lymphocyte culture as an in vitro model for allogeneic reaction. To prove the in vivo relevance, an ex vivo experimental setup was established. This involved participants taking zinc orally for 1 week. Here it is shown that in vivo zinc application induced the same effect of blocking the mixed lymphocyte culture without influencing tetanus toxoid stimulation. So far, no clinical application studies have been performed, but the observed selective suppression of allogeneic reaction by zinc is the first step towards a new generation of immunosuppressants.

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Acknowledgements

We thank Romney Haylett for critical reading of the manuscript.

Author information

Authors and Affiliations

  1. Institute of Immunology and Transfusion Medicine, University of Lübeck School of Medicine, Lübeck, Germany

    C Faber & P Gabriel

  2. Institute of Immunology, University Hospital, Rhine-Westfalia-Technical University of Aachen, Aachen, Germany

    K-H Ibs & L Rink

Authors
  1. C Faber
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  2. P Gabriel
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  3. K-H Ibs
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  4. L Rink
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Correspondence to L Rink.

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Faber, C., Gabriel, P., Ibs, KH. et al. Zinc in pharmacological doses suppresses allogeneic reaction without affecting the antigenic response. Bone Marrow Transplant 33, 1241–1246 (2004). https://doi.org/10.1038/sj.bmt.1704509

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