During infection, pathogenic Yersinia species secrete the antiphagocytic factor YopO (or YpkA), which contains a kinase domain and a Rho GTPase guanine nucleotide–dissociation inhibitor (GDI) domain. The structure of YopO in complex with actin, along with biochemical analyses, reveals the mechanism by which YopO uses actin to activate its kinase domain and recruit, phosphorylate and deactivate actin-assembly factors implicated in phagocytic clearance of the bacterium.
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References
Welch, M.D. & Way, M. Cell Host Microbe 14, 242–255 (2013).
Haglund, C.M. & Welch, M.D. J. Cell Biol. 195, 7–17 (2011).
Taylor, M.P., Koyuncu, O.O. & Enquist, L.W. Nat. Rev. Microbiol. 9, 427–439 (2011).
Aktories, K., Lang, A.E., Schwan, C. & Mannherz, H.G. FEBS J. 278, 4526–4543 (2011).
Carabeo, R. Cell. Microbiol. 13, 1460–1469 (2011).
Lee, W.L., Grimes, J.M. & Robinson, R.C. Nat. Struct. Mol. Biol. 22, 248–255 (2015).
Matsumoto, H. & Young, G.M. Curr. Opin. Microbiol. 12, 94–100 (2009).
Viboud, G.I. & Bliska, J.B. Annu. Rev. Microbiol. 59, 69–89 (2005).
Hall, A. Biochem. Soc. Trans. 40, 1378–1382 (2012).
Håkansson, S., Galyov, E.E., Rosqvist, R. & Wolf-Watz, H. Mol. Microbiol. 20, 593–603 (1996).
Trasak, C. et al. J. Biol. Chem. 282, 2268–2277 (2007).
Juris, S.J., Rudolph, A.E., Huddler, D., Orth, K. & Dixon, J.E. Proc. Natl. Acad. Sci. USA 97, 9431–9436 (2000).
Prehna, G., Ivanov, M.I., Bliska, J.B. & Stebbins, C.E. Cell 126, 869–880 (2006).
Wiley, D.J. et al. Microb. Pathog. 40, 234–243 (2006).
Nejedlik, L., Pierfelice, T. & Geiser, J.R. Yeast 21, 759–768 (2004).
Groves, E. et al. J. Biol. Chem. 285, 4087–4098 (2010).
Galyov, E.E., Hakansson, S., Forsberg, A. & Wolf-Watz, H. Nature 361, 730–732 (1993).
Dominguez, R. & Holmes, K.C. Annu. Rev. Biophys. 40, 169–186 (2011).
Lee, S.H., Hayes, D.B., Rebowski, G., Tardieux, I. & Dominguez, R. Proc. Natl. Acad. Sci. USA 104, 16122–16127 (2007).
Ke, Y. et al. Cell. Microbiol. doi:10.1111/cmi.12378 (22 November 2014).
Acknowledgements
R.D. was supported by US National Institutes of Health R01 grants MH087950 and GM073791.
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Dominguez, R. Subversive bacteria reveal new tricks in their cytoskeleton-hijacking arsenal. Nat Struct Mol Biol 22, 178–179 (2015). https://doi.org/10.1038/nsmb.2976
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DOI: https://doi.org/10.1038/nsmb.2976