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Nod-like proteins in immunity, inflammation and disease

Nature Immunology volume 7, pages 1250–1257 (2006)Cite this article

Abstract

The intracellular Nod-like proteins or receptors are a family of sensors of intracellularly encountered microbial motifs and 'danger signals' that have emerged as being critical components of the innate immune responses and of inflammation in mammals. Several Nod-like receptors, including Nod1, Nod2, NALP3, Ipaf and Naip, are strongly associated with host responses to intracellular invasion by bacteria or the intracellular presence of specific bacterial products. An additional key function of Nod-like receptors is in inflammatory conditions, which has been emphasized by the identification of several different mutations in the genes encoding Nod1, Nod2 and NALP3 that are associated with susceptibility to inflammatory disorders. Those and other issues related to the Nod-like receptor family are discussed here.

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Figure 1: NLRs, homologs and adaptors.
Figure 2: NLR activation by microbes, PAMPs and danger signals in mammalian cells.

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Acknowledgements

Supported by the National Health and Medical Research Council of Australia (R.L.F.), the ANZ Charitable Trust (R.L.F.), the Canadian Institutes for Health Research (D.J.P. and S.E.G.) and the Austrian Science Fund (Erwin Schrödinger Research Fellowship J2630 to J.H.F.).

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  1. Department of Immunology, Medical Sciences Building, University of Toronto, Toronto, M5S 1A8, Ontario, Canada

    Jörg H Fritz & Dana J Philpott

  2. Department of Microbiology, Monash University, Clayton, 3800, Victoria, Australia

    Richard L Ferrero

  3. Department of Laboratory Medicine and Pathobiology, Medical Sciences Building, University of Toronto, Toronto, M5S 1A8, Ontario, Canada

    Stephen E Girardin

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Fritz, J., Ferrero, R., Philpott, D. et al. Nod-like proteins in immunity, inflammation and disease. Nat Immunol 7, 1250–1257 (2006). https://doi.org/10.1038/ni1412

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