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Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking

Nature Immunology volume 9, pages 981–987 (2008)Cite this article

Abstract

Lymphocytes are imprinted during activation with trafficking programs (combinations of adhesion and chemoattractant receptors) that target their migration to specific tissues and microenvironments. Cytokines contribute, but, for gut and skin, evolution has cleverly adapted external cues from food (vitamin A) and sunlight (ultraviolet-induced vitamin D3) to imprint lymphocyte homing to the small intestines and T cell migration into the epidermis. Dendritic cells are essential: they process the vitamins to their active metabolites (retinoic acid and 1,25(OH)2D3) for presentation with antigen to lymphocytes, and they help export environmental cues through lymphatics to draining lymph nodes, to program the trafficking and effector functions of naive T and B cells.

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Figure 1: Vitamin A and the imprinting of small intestine trafficking.

Katie Ris-Vicari

Figure 2: Sunshine, vitamin D3 and T cell epidermotropism.

Katie Ris-Vicari

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Acknowledgements

We thank A. Habtezion and C. Oderup for critical comments on the manuscript. Supported by Ruth L. Kirschstein National Research Service Award AI 66835-01A1 (H.S.); by US National Institutes of Health (NIH) grants AI72618, AI47822, AI059635, GM37734 and U19 AI057229 and a Merit Award from the Department of Veterans Affairs (E.C.B.); and by the FACS Core Facility of the Stanford Digestive Disease Center under NIH grant P30 DK56339.

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  1. Department of Pathology, Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine, Stanford, 94305, California, USA

    Hekla Sigmundsdottir & Eugene C Butcher

  2. The Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, 94304, California, USA

    Hekla Sigmundsdottir & Eugene C Butcher

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Correspondence to Eugene C Butcher.

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Sigmundsdottir, H., Butcher, E. Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking. Nat Immunol 9, 981–987 (2008). https://doi.org/10.1038/ni.f.208

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