Differentiation of neuronal stem cells into astrocytes or neurons is important in maintaining brain function. Oxidative stress and inflammation are now shown to bias differentiation toward astrocytes by modulating activity of the anti-ageing gene Sirt1. These findings link a longevity gene to the activity of neuronal stem cells and their response to stress.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Momordica charantia polysaccharides modulate the differentiation of neural stem cells via SIRT1/Β-catenin axis in cerebral ischemia/reperfusion
Stem Cell Research & Therapy Open Access 16 November 2020
-
Antisense miR-132 blockade via the AChE-R splice variant mitigates cortical inflammation
Scientific Reports Open Access 17 February 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
£139.00 per year
only £11.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Prozorovski et al. Nature Cell Biol. 10, 385–394 (2008).
Nemoto, S., Fergusson, M. M. & Finkel, T. J. Biol. Chem. 280, 16456–16460 (2005).
Li, X. et al. Mol. Cell 28, 91–106 (2007).
Luo, J. et al. Cell 107, 137–148 (2001).
Kim, D. et al. EMBO J. 26, 3169–3179 (2007).
Qin, W. et al. J. Biol. Chem. 281, 21745–21754 (2006).
Araki, T., Sasaki, Y. & Milbrandt, J. Science 305, 1010–1013 (2004).
Bishop, N. A. & Guarente, L. Nature 447, 545–549 (2007).
Libert, S. et al. Science 315, 1133–1137 (2007).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Libert, S., Cohen, D. & Guarente, L. Neurogenesis directed by Sirt1. Nat Cell Biol 10, 373–374 (2008). https://doi.org/10.1038/ncb0408-373
Issue Date:
DOI: https://doi.org/10.1038/ncb0408-373
This article is cited by
-
Momordica charantia polysaccharides modulate the differentiation of neural stem cells via SIRT1/Β-catenin axis in cerebral ischemia/reperfusion
Stem Cell Research & Therapy (2020)
-
Recovery of Olfactory Function After Excitotoxic Lesion of the Olfactory Bulbs Is Associated with Increases in Bulbar SIRT1 and SIRT4 Expressions
Molecular Neurobiology (2019)
-
Antisense miR-132 blockade via the AChE-R splice variant mitigates cortical inflammation
Scientific Reports (2017)
-
Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome
Molecular Neurobiology (2017)
-
Neurodegeneration in Parkinson's Disease: Interactions of Oxidative Stress, Tryptophan Catabolites and Depression with Mitochondria and Sirtuins
Molecular Neurobiology (2014)